GABAergic transmission in temporal lobe epilepsy: The role of neurosteroids

Suchitra Joshi, Karthik Rajasekaran, Jaideep Kapur

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Modification of GABAergic inhibition is an intensely investigated hypothesis guiding research into mechanisms underlying temporal lobe epilepsy (TLE). Seizures can be initiated by blocking γ amino butyric acid type A (GABAA receptors, GABARs), which mediate fast synaptic inhibition in the brain, and controlled by drugs that enhance their function. Derivatives of steroid hormones called neurosteroids are natural substances that physiologically enhance GABAR function and suppress seizures. GABAR structure, function, expression, assembly, and pharmacological properties are changed in the hippocampus of epileptic animals. These alterations render GABARs less sensitive to neurosteroid modulation, which may contribute to seizure susceptibility. Plasticity of GABARs could play a role in periodic exacerbation of seizures experienced by women with epilepsy, commonly referred to as catamenial epilepsy.

Original languageEnglish (US)
Pages (from-to)36-42
Number of pages7
JournalExperimental Neurology
Volume244
DOIs
StatePublished - Jun 1 2013

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Keywords

  • GABA-A receptors
  • Neurosteroids
  • Pharmacology
  • Physiology
  • Temporal lobe epilepsy
  • Trafficking

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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