Gallbladder cancer

The role of laparoscopy and radical resection

Samuel P. Shih, Richard D. Schulick, John L. Cameron, Keith D. Lillemoe, Henry A. Pitt, Michael A. Choti, Kurtis A. Campbell, Charles J. Yeo, Mark A. Talamini

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

OBJECTIVES: We assess how laparoscopy has altered the presentation of patients with gallbladder cancer and determine whether radical resection in patients with gallbladder cancer is beneficial. SUMMARY BACKGROUND DATA: The widespread adoption of laparoscopic cholecystectomy has led to an increased frequency of incidentally discovered gallbladder carcinoma. Little data exist to guide surgeons in the optimum management of patients with gallbladder cancer, particularly with respect to the potential advantages of radical resection. METHODS: Records of 107 patients with gallbladder cancer admitted to a tertiary academic medical center between 1995 and 2004 were reviewed. Gallbladder cancer was found incidentally in 53 patients (50%). Fifty-two of these patients underwent a routine laparoscopic cholecystectomy and were found to have gallbladder cancer intraoperatively or following the operation by subsequent pathologic evaluation of the specimen. Gallbladder cancer had been diagnosed preoperatively by radiology in the other 54 patients (50%). These patients did not undergo laparoscopic cholecystectomy and were explored electively. RESULTS: The median age at presentation was 67 years and 66% were female. Patients who were found to have gallbladder carcinoma incidentally at laparoscopic cholecystectomy had a significant increase in survival when compared with those who were admitted electively with a known diagnosis (P < 0.001). All patients who presented with a known diagnosis had stage II or greater disease, and 36% of these were stage IV carcinomas. However, 82% of those patients who were found incidentally were stage I or II. The overall 5-year survival for all patients was 15%; those discovered incidentally at laparoscopic cholecystectomy had a 5-year survival of 33%. This difference was significant among patients with stage II carcinomas. In the laparoscopic group, there was no difference in survival between the patients who were immediately converted to an open resection when identified to have gallbladder cancer intraoperatively (n = 6) and those who had a completed laparoscopic cholecystectomy and were re-explored at a later point when found to have gallbladder cancer by subsequent pathology (n = 33). There was a significant improvement in survival in 50 patients (47%) who underwent some form of radical resection (P < 0.001). Stage for stage comparison showed that this was significant in stage II disease. Patients who underwent hepatic resection along with lymphadenectomy and extra hepatic biliary resection had similar survival compared with those who had hepatic resection and lymphadenectomy alone. CONCLUSIONS: Laparoscopic cholecystectomy appears to have resulted in the earlier discovery of gallbladder cancer in some patients, resulting in increased probability of survival. Patients discovered with gallbladder carcinoma during a laparoscopic cholecystectomy do not have to be converted immediately to an open resection and should be referred to a tertiary care center for further exploration. Adjunctive radical surgical resection, either at the time of cholecystectomy or subsequently, increases survival significantly in early stage disease.

Original languageEnglish (US)
Pages (from-to)893-901
Number of pages9
JournalAnnals of Surgery
Volume245
Issue number6
DOIs
StatePublished - Jun 2007

Fingerprint

Gallbladder Neoplasms
Laparoscopy
Laparoscopic Cholecystectomy
Survival
Carcinoma
Gallbladder
Lymph Node Excision
Liver

ASJC Scopus subject areas

  • Surgery

Cite this

Shih, S. P., Schulick, R. D., Cameron, J. L., Lillemoe, K. D., Pitt, H. A., Choti, M. A., ... Talamini, M. A. (2007). Gallbladder cancer: The role of laparoscopy and radical resection. Annals of Surgery, 245(6), 893-901. https://doi.org/10.1097/SLA.0b013e31806beec2

Gallbladder cancer : The role of laparoscopy and radical resection. / Shih, Samuel P.; Schulick, Richard D.; Cameron, John L.; Lillemoe, Keith D.; Pitt, Henry A.; Choti, Michael A.; Campbell, Kurtis A.; Yeo, Charles J.; Talamini, Mark A.

In: Annals of Surgery, Vol. 245, No. 6, 06.2007, p. 893-901.

Research output: Contribution to journalArticle

Shih, SP, Schulick, RD, Cameron, JL, Lillemoe, KD, Pitt, HA, Choti, MA, Campbell, KA, Yeo, CJ & Talamini, MA 2007, 'Gallbladder cancer: The role of laparoscopy and radical resection', Annals of Surgery, vol. 245, no. 6, pp. 893-901. https://doi.org/10.1097/SLA.0b013e31806beec2
Shih SP, Schulick RD, Cameron JL, Lillemoe KD, Pitt HA, Choti MA et al. Gallbladder cancer: The role of laparoscopy and radical resection. Annals of Surgery. 2007 Jun;245(6):893-901. https://doi.org/10.1097/SLA.0b013e31806beec2
Shih, Samuel P. ; Schulick, Richard D. ; Cameron, John L. ; Lillemoe, Keith D. ; Pitt, Henry A. ; Choti, Michael A. ; Campbell, Kurtis A. ; Yeo, Charles J. ; Talamini, Mark A. / Gallbladder cancer : The role of laparoscopy and radical resection. In: Annals of Surgery. 2007 ; Vol. 245, No. 6. pp. 893-901.
@article{b6521cdb53e140718e81fbb85aa36bac,
title = "Gallbladder cancer: The role of laparoscopy and radical resection",
abstract = "OBJECTIVES: We assess how laparoscopy has altered the presentation of patients with gallbladder cancer and determine whether radical resection in patients with gallbladder cancer is beneficial. SUMMARY BACKGROUND DATA: The widespread adoption of laparoscopic cholecystectomy has led to an increased frequency of incidentally discovered gallbladder carcinoma. Little data exist to guide surgeons in the optimum management of patients with gallbladder cancer, particularly with respect to the potential advantages of radical resection. METHODS: Records of 107 patients with gallbladder cancer admitted to a tertiary academic medical center between 1995 and 2004 were reviewed. Gallbladder cancer was found incidentally in 53 patients (50{\%}). Fifty-two of these patients underwent a routine laparoscopic cholecystectomy and were found to have gallbladder cancer intraoperatively or following the operation by subsequent pathologic evaluation of the specimen. Gallbladder cancer had been diagnosed preoperatively by radiology in the other 54 patients (50{\%}). These patients did not undergo laparoscopic cholecystectomy and were explored electively. RESULTS: The median age at presentation was 67 years and 66{\%} were female. Patients who were found to have gallbladder carcinoma incidentally at laparoscopic cholecystectomy had a significant increase in survival when compared with those who were admitted electively with a known diagnosis (P < 0.001). All patients who presented with a known diagnosis had stage II or greater disease, and 36{\%} of these were stage IV carcinomas. However, 82{\%} of those patients who were found incidentally were stage I or II. The overall 5-year survival for all patients was 15{\%}; those discovered incidentally at laparoscopic cholecystectomy had a 5-year survival of 33{\%}. This difference was significant among patients with stage II carcinomas. In the laparoscopic group, there was no difference in survival between the patients who were immediately converted to an open resection when identified to have gallbladder cancer intraoperatively (n = 6) and those who had a completed laparoscopic cholecystectomy and were re-explored at a later point when found to have gallbladder cancer by subsequent pathology (n = 33). There was a significant improvement in survival in 50 patients (47{\%}) who underwent some form of radical resection (P < 0.001). Stage for stage comparison showed that this was significant in stage II disease. Patients who underwent hepatic resection along with lymphadenectomy and extra hepatic biliary resection had similar survival compared with those who had hepatic resection and lymphadenectomy alone. CONCLUSIONS: Laparoscopic cholecystectomy appears to have resulted in the earlier discovery of gallbladder cancer in some patients, resulting in increased probability of survival. Patients discovered with gallbladder carcinoma during a laparoscopic cholecystectomy do not have to be converted immediately to an open resection and should be referred to a tertiary care center for further exploration. Adjunctive radical surgical resection, either at the time of cholecystectomy or subsequently, increases survival significantly in early stage disease.",
author = "Shih, {Samuel P.} and Schulick, {Richard D.} and Cameron, {John L.} and Lillemoe, {Keith D.} and Pitt, {Henry A.} and Choti, {Michael A.} and Campbell, {Kurtis A.} and Yeo, {Charles J.} and Talamini, {Mark A.}",
year = "2007",
month = "6",
doi = "10.1097/SLA.0b013e31806beec2",
language = "English (US)",
volume = "245",
pages = "893--901",
journal = "Annals of Surgery",
issn = "0003-4932",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Gallbladder cancer

T2 - The role of laparoscopy and radical resection

AU - Shih, Samuel P.

AU - Schulick, Richard D.

AU - Cameron, John L.

AU - Lillemoe, Keith D.

AU - Pitt, Henry A.

AU - Choti, Michael A.

AU - Campbell, Kurtis A.

AU - Yeo, Charles J.

AU - Talamini, Mark A.

PY - 2007/6

Y1 - 2007/6

N2 - OBJECTIVES: We assess how laparoscopy has altered the presentation of patients with gallbladder cancer and determine whether radical resection in patients with gallbladder cancer is beneficial. SUMMARY BACKGROUND DATA: The widespread adoption of laparoscopic cholecystectomy has led to an increased frequency of incidentally discovered gallbladder carcinoma. Little data exist to guide surgeons in the optimum management of patients with gallbladder cancer, particularly with respect to the potential advantages of radical resection. METHODS: Records of 107 patients with gallbladder cancer admitted to a tertiary academic medical center between 1995 and 2004 were reviewed. Gallbladder cancer was found incidentally in 53 patients (50%). Fifty-two of these patients underwent a routine laparoscopic cholecystectomy and were found to have gallbladder cancer intraoperatively or following the operation by subsequent pathologic evaluation of the specimen. Gallbladder cancer had been diagnosed preoperatively by radiology in the other 54 patients (50%). These patients did not undergo laparoscopic cholecystectomy and were explored electively. RESULTS: The median age at presentation was 67 years and 66% were female. Patients who were found to have gallbladder carcinoma incidentally at laparoscopic cholecystectomy had a significant increase in survival when compared with those who were admitted electively with a known diagnosis (P < 0.001). All patients who presented with a known diagnosis had stage II or greater disease, and 36% of these were stage IV carcinomas. However, 82% of those patients who were found incidentally were stage I or II. The overall 5-year survival for all patients was 15%; those discovered incidentally at laparoscopic cholecystectomy had a 5-year survival of 33%. This difference was significant among patients with stage II carcinomas. In the laparoscopic group, there was no difference in survival between the patients who were immediately converted to an open resection when identified to have gallbladder cancer intraoperatively (n = 6) and those who had a completed laparoscopic cholecystectomy and were re-explored at a later point when found to have gallbladder cancer by subsequent pathology (n = 33). There was a significant improvement in survival in 50 patients (47%) who underwent some form of radical resection (P < 0.001). Stage for stage comparison showed that this was significant in stage II disease. Patients who underwent hepatic resection along with lymphadenectomy and extra hepatic biliary resection had similar survival compared with those who had hepatic resection and lymphadenectomy alone. CONCLUSIONS: Laparoscopic cholecystectomy appears to have resulted in the earlier discovery of gallbladder cancer in some patients, resulting in increased probability of survival. Patients discovered with gallbladder carcinoma during a laparoscopic cholecystectomy do not have to be converted immediately to an open resection and should be referred to a tertiary care center for further exploration. Adjunctive radical surgical resection, either at the time of cholecystectomy or subsequently, increases survival significantly in early stage disease.

AB - OBJECTIVES: We assess how laparoscopy has altered the presentation of patients with gallbladder cancer and determine whether radical resection in patients with gallbladder cancer is beneficial. SUMMARY BACKGROUND DATA: The widespread adoption of laparoscopic cholecystectomy has led to an increased frequency of incidentally discovered gallbladder carcinoma. Little data exist to guide surgeons in the optimum management of patients with gallbladder cancer, particularly with respect to the potential advantages of radical resection. METHODS: Records of 107 patients with gallbladder cancer admitted to a tertiary academic medical center between 1995 and 2004 were reviewed. Gallbladder cancer was found incidentally in 53 patients (50%). Fifty-two of these patients underwent a routine laparoscopic cholecystectomy and were found to have gallbladder cancer intraoperatively or following the operation by subsequent pathologic evaluation of the specimen. Gallbladder cancer had been diagnosed preoperatively by radiology in the other 54 patients (50%). These patients did not undergo laparoscopic cholecystectomy and were explored electively. RESULTS: The median age at presentation was 67 years and 66% were female. Patients who were found to have gallbladder carcinoma incidentally at laparoscopic cholecystectomy had a significant increase in survival when compared with those who were admitted electively with a known diagnosis (P < 0.001). All patients who presented with a known diagnosis had stage II or greater disease, and 36% of these were stage IV carcinomas. However, 82% of those patients who were found incidentally were stage I or II. The overall 5-year survival for all patients was 15%; those discovered incidentally at laparoscopic cholecystectomy had a 5-year survival of 33%. This difference was significant among patients with stage II carcinomas. In the laparoscopic group, there was no difference in survival between the patients who were immediately converted to an open resection when identified to have gallbladder cancer intraoperatively (n = 6) and those who had a completed laparoscopic cholecystectomy and were re-explored at a later point when found to have gallbladder cancer by subsequent pathology (n = 33). There was a significant improvement in survival in 50 patients (47%) who underwent some form of radical resection (P < 0.001). Stage for stage comparison showed that this was significant in stage II disease. Patients who underwent hepatic resection along with lymphadenectomy and extra hepatic biliary resection had similar survival compared with those who had hepatic resection and lymphadenectomy alone. CONCLUSIONS: Laparoscopic cholecystectomy appears to have resulted in the earlier discovery of gallbladder cancer in some patients, resulting in increased probability of survival. Patients discovered with gallbladder carcinoma during a laparoscopic cholecystectomy do not have to be converted immediately to an open resection and should be referred to a tertiary care center for further exploration. Adjunctive radical surgical resection, either at the time of cholecystectomy or subsequently, increases survival significantly in early stage disease.

UR - http://www.scopus.com/inward/record.url?scp=34249325177&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249325177&partnerID=8YFLogxK

U2 - 10.1097/SLA.0b013e31806beec2

DO - 10.1097/SLA.0b013e31806beec2

M3 - Article

VL - 245

SP - 893

EP - 901

JO - Annals of Surgery

JF - Annals of Surgery

SN - 0003-4932

IS - 6

ER -