Gastric function and obesity: Gastric emptying, gastric acid secretion, and plasma pepsinogen

H. Sasaki, M. Nagulesparan, A. Dubois, I. M. Samloff, E. Straus, M. L. Sievers, Roger H Unger

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Because rapid gastric emptying and a shortened satiety period might contribute to development of obesity, this study compared gastric emptying of acaloric liquid, gastric acid production, and plasma levels of gastrin and pepsinogen I (PG I) and II (PG II) among obese and nonobese Pima Indians. Rates of fractional gastric emptying and of gastric acid secretion were similar in the two groups, basally and after an acaloric liquid meal. Basal and postprandial plasma gastrin levels did not differ significantly in obese and nonobese Pimas, but peak betazole-stimulated gastric acid output was greater in the obese group, except when normalized by body weight. The plasma PG I and PG II concentrations and PG I/PG II ratio did not differ significantly between the two groups, but the PG I/PG II ratio had a positive correlation with peak acid output. No correlation was found between fractional gastric emptying rate and degree of obesity. We conclude that an increased gastric emptying rate for liquid does not contribute to the pathogenesis of obesity in Pima Indians.

Original languageEnglish (US)
Pages (from-to)183-190
Number of pages8
JournalInternational Journal of Obesity
Volume8
Issue number2
StatePublished - 1984

Fingerprint

Pepsinogen A
gastric acid
pepsinogen
gastric emptying
Gastric Emptying
Gastric Acid
Stomach
stomach
obesity
Obesity
secretion
Potassium Iodide
gastrins
liquids
Betazole
Pepsinogen C
Gastrins
satiety
Meals
pathogenesis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Sasaki, H., Nagulesparan, M., Dubois, A., Samloff, I. M., Straus, E., Sievers, M. L., & Unger, R. H. (1984). Gastric function and obesity: Gastric emptying, gastric acid secretion, and plasma pepsinogen. International Journal of Obesity, 8(2), 183-190.

Gastric function and obesity : Gastric emptying, gastric acid secretion, and plasma pepsinogen. / Sasaki, H.; Nagulesparan, M.; Dubois, A.; Samloff, I. M.; Straus, E.; Sievers, M. L.; Unger, Roger H.

In: International Journal of Obesity, Vol. 8, No. 2, 1984, p. 183-190.

Research output: Contribution to journalArticle

Sasaki, H, Nagulesparan, M, Dubois, A, Samloff, IM, Straus, E, Sievers, ML & Unger, RH 1984, 'Gastric function and obesity: Gastric emptying, gastric acid secretion, and plasma pepsinogen', International Journal of Obesity, vol. 8, no. 2, pp. 183-190.
Sasaki H, Nagulesparan M, Dubois A, Samloff IM, Straus E, Sievers ML et al. Gastric function and obesity: Gastric emptying, gastric acid secretion, and plasma pepsinogen. International Journal of Obesity. 1984;8(2):183-190.
Sasaki, H. ; Nagulesparan, M. ; Dubois, A. ; Samloff, I. M. ; Straus, E. ; Sievers, M. L. ; Unger, Roger H. / Gastric function and obesity : Gastric emptying, gastric acid secretion, and plasma pepsinogen. In: International Journal of Obesity. 1984 ; Vol. 8, No. 2. pp. 183-190.
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