GC–MS based metabolomics used for the identification of cancer volatile organic compounds as biomarkers

Giuseppe Lubes, Mohammad Goodarzi

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

A biomarker can be a metabolite, coming from a metabolic pathway or cell process, which might be employed in the diagnostic of diseases, predict patient response towards chemical therapies and/or monitor disease recurrences. Biomarkers, e.g. aldehydes or hydrocarbons, are often identified from different body fluids such as blood, urine, serum, saliva or from various tissues samples, and their concentration can vary from one sample to the other. However, the detection and the action of these biomarkers for diseases is a complicated process. Cancer is one of the main cause of death worldwide. The main characteristic of cancerous tumor is the uncontrolled growing of cells inside the organism. Likely, these uncontrolled growths are as consequence changes in the metabolism that could be analytically monitored. Depending on where the cancer cells are located, they provide different characteristics profiles. These profiles as fingerprints are used for differentiation in a comparison to normal cells. This critical study aimed at highlighting the latest progress in this area, especially in the employment of gas chromatography for the monitoring of volatile organic compounds (VOCs) and the identification of possible molecules used as biomarkers for cancer therapy.

Original languageEnglish (US)
Pages (from-to)313-322
Number of pages10
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume147
DOIs
StatePublished - Jan 5 2018

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Volatile Organic Compounds
Metabolomics
Biomarkers
Gas Chromatography-Mass Spectrometry
Neoplasms
Body fluids
Tumor Biomarkers
Metabolites
Hydrocarbons
Metabolism
Aldehydes
Gas chromatography
Tumors
Dermatoglyphics
Body Fluids
Blood
Metabolic Networks and Pathways
Saliva
Cells
Gas Chromatography

Keywords

  • Cancer
  • GC–MS
  • Metabolites
  • Metabolomics
  • VOCs

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

Cite this

GC–MS based metabolomics used for the identification of cancer volatile organic compounds as biomarkers. / Lubes, Giuseppe; Goodarzi, Mohammad.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 147, 05.01.2018, p. 313-322.

Research output: Contribution to journalReview article

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