Gender dependent importance of IRAK-1 in dextran sulfate sodium induced colitis

Martin Berglund, James A. Thomas, Maria Fritsch Fredin, Silvia Melgar, Elisabeth H. Hörnquist, Olof H. Hultgren

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Toll-like receptor (TLR) signaling is important for the induction of pro-inflammatory cytokines and interferon (IFN)-inducible genes in response to bacterial and viral challenge. Interleukin-1 receptor-associated kinase-1 (IRAK-1) is a signaling kinase situated downstream of the adapter protein myeloid differentiation factor 88 (MyD88) in the TLR intracellular signaling cascade and is required for normal signal transduction through this pathway. We investigated the importance of IRAK-1 in intestinal inflammation by using the dextran sulfate sodium (DSS)-colitis model. We show that IRAK-1 deficient mice are protected against systemic signs of inflammation, i.e., weight loss and spleen enlargement compared to wild-type controls irrespective of gender. However, IRAK-1-/y males but not IRAK-1-/- females display significant protection against colitis and thymic atrophy compared to wild-type mice. Our results indicate a gender specific effect of IRAK-1 in the DSS-induced colitis, an interesting finding since the Irak-1 gene is located on the X-chromosome and several inflammatory diseases have a gender dependent incidence.

Original languageEnglish (US)
Pages (from-to)27-32
Number of pages6
JournalCellular Immunology
Volume259
Issue number1
DOIs
StatePublished - Jun 19 2009

Keywords

  • Intestinal inflammation
  • Mucosal immunity
  • TLR-signaling

ASJC Scopus subject areas

  • Immunology

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    Berglund, M., Thomas, J. A., Fredin, M. F., Melgar, S., Hörnquist, E. H., & Hultgren, O. H. (2009). Gender dependent importance of IRAK-1 in dextran sulfate sodium induced colitis. Cellular Immunology, 259(1), 27-32. https://doi.org/10.1016/j.cellimm.2009.05.009