TY - JOUR
T1 - Gene expression profiling of plasma cells at myeloma relapse from tandem transplantation trial Total Therapy 2 predicts subsequent survival
AU - Nair, Bijay
AU - Shaughnessy, John D.
AU - Zhou, Yiming
AU - Astrid-Cartron, Marie
AU - Qu, Pingping
AU - Van Rhee, Frits
AU - Anaissie, Elias
AU - Alsayed, Yazan
AU - Waheed, Sarah
AU - Hollmig, Klaus
AU - Szymonifka, Jackie
AU - Petty, Nathan
AU - Hoering, Antje
AU - Barlogie, Bart
PY - 2009
Y1 - 2009
N2 - We report on prognostic implications for postrelapse survival (PRS) of a gene expression profiling (GEP)-defined risk score at relapse available in 120 myeloma patients previously enrolled in tandem transplantation trial Total Therapy 2. Among the 71 patients with additional GEP baseline information, 3-year PRS was 71% in 40 patients with low risk present both at baseline and relapse contrasting with only 17% in 28 patients with high risk at relapse, 12 of whom with baseline low-risk status fared better than the remainder (P = .08). On multivariate analysis of relapse parameters available in 104 patients, high risk conferred short PRS (hazard ratio = 4.00, P < .001, R2 = 33%), whereas relapse hyperdiploidy predicted long PRS (hazard ratio = 0.37, P = .022, cumulative R2 = 41%). In case the initial partial response lasted less than 2 years, relapse low-risk identi-fied 26 patients with superior 3-year PRS of 61% versus 9% among 32 with relapse high-risk (P < .001). Based on its PRS predictive power, GEP analysis should be an integral part of new agent trials in search of better therapy for high-risk myeloma.
AB - We report on prognostic implications for postrelapse survival (PRS) of a gene expression profiling (GEP)-defined risk score at relapse available in 120 myeloma patients previously enrolled in tandem transplantation trial Total Therapy 2. Among the 71 patients with additional GEP baseline information, 3-year PRS was 71% in 40 patients with low risk present both at baseline and relapse contrasting with only 17% in 28 patients with high risk at relapse, 12 of whom with baseline low-risk status fared better than the remainder (P = .08). On multivariate analysis of relapse parameters available in 104 patients, high risk conferred short PRS (hazard ratio = 4.00, P < .001, R2 = 33%), whereas relapse hyperdiploidy predicted long PRS (hazard ratio = 0.37, P = .022, cumulative R2 = 41%). In case the initial partial response lasted less than 2 years, relapse low-risk identi-fied 26 patients with superior 3-year PRS of 61% versus 9% among 32 with relapse high-risk (P < .001). Based on its PRS predictive power, GEP analysis should be an integral part of new agent trials in search of better therapy for high-risk myeloma.
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UR - http://www.scopus.com/inward/citedby.url?scp=70449496661&partnerID=8YFLogxK
U2 - 10.1182/blood-2009-02-207803
DO - 10.1182/blood-2009-02-207803
M3 - Article
C2 - 19389881
AN - SCOPUS:70449496661
SN - 0006-4971
VL - 113
SP - 3572
EP - 3575
JO - Blood
JF - Blood
IS - 26
ER -