Gene Expression Regulation: Activity-Dependent

E. D. Nelson; Lisa M Monteggia

doi:10.1016/B978-008045046-9.00170-4

Gene Expression Regulation: Activity-Dependent

E. D. Nelson, Lisa M Monteggia

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Regulation of gene expression changes is thought to be the basis for long-lasting forms of synaptic plasticity in the brain. Paradoxically, synaptic activity can regulate the transcription of some of the genes responsible for the changes in synaptic plasticity. In this article we discuss how synaptic activity can affect gene expression through both transcriptional activators and repressors as well as through epigenetic mechanisms, such as DNA methylation and histone acetylation, that are important for controlling gene transcription.

Original language	English (US)
Title of host publication	Encyclopedia of Neuroscience
Publisher	Elsevier Ltd
Pages	605-609
Number of pages	5
ISBN (Print)	9780080450469
DOIs	https://doi.org/10.1016/B978-008045046-9.00170-4
State	Published - 2009

Keywords

Gene expression
Synaptic activity
Transcriptional activation
Transcriptional repression

ASJC Scopus subject areas

General Neuroscience

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10.1016/B978-008045046-9.00170-4

Cite this

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AB - Regulation of gene expression changes is thought to be the basis for long-lasting forms of synaptic plasticity in the brain. Paradoxically, synaptic activity can regulate the transcription of some of the genes responsible for the changes in synaptic plasticity. In this article we discuss how synaptic activity can affect gene expression through both transcriptional activators and repressors as well as through epigenetic mechanisms, such as DNA methylation and histone acetylation, that are important for controlling gene transcription.

KW - Gene expression

KW - Synaptic activity

KW - Transcriptional activation

KW - Transcriptional repression

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BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd

ER -

Gene Expression Regulation: Activity-Dependent

Abstract

Keywords

ASJC Scopus subject areas

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