Gene Expression Regulation: Activity-Dependent

E. D. Nelson, Lisa M Monteggia

Research output: Chapter in Book/Report/Conference proceedingChapter


Regulation of gene expression changes is thought to be the basis for long-lasting forms of synaptic plasticity in the brain. Paradoxically, synaptic activity can regulate the transcription of some of the genes responsible for the changes in synaptic plasticity. In this article we discuss how synaptic activity can affect gene expression through both transcriptional activators and repressors as well as through epigenetic mechanisms, such as DNA methylation and histone acetylation, that are important for controlling gene transcription.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages5
ISBN (Print)9780080450469
StatePublished - 2009


  • Gene expression
  • Synaptic activity
  • Transcriptional activation
  • Transcriptional repression

ASJC Scopus subject areas

  • Neuroscience(all)


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