Genes of the major histocompatibility complex

L. Hood, M. Steinmetz, R. Goodenow, K. Eakle, D. Fisher, J. Kobori, B. Malissen, M. Malissen, M. McMillan, J. McNicholas, A. Orn, M. Pecht, B. T. Sher, L. Smith, I. Stroynowski, H. Sun, A. Winoto, M. Zuniga

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The major histocompatibility complex (MHC) of vertebrates encodes several classes of cell-surface proteins that play a critical role in regulating immune responses. Class-I gene code for the transplantation antigens, which are required for the lysis of virally infected or neoplastically transformed cells by cytotoxic T cells (T-cell immunosurveillance). Class-II genes produce cell-surface molecules on bone-marrow-derived cells (B cells, T cells, macrophages) that play a role in the cellular interactions leading to the induction of immune responses. A third family of genes, the class-III genes, encode components of the activation portion of the complement pathway. In this paper we discuss our studies involving the class-I and class-II genes of the inbred BALB/c mouse. These studies provide information about the organization of the MHC on chromosome 17 of the mouse.

Original languageEnglish (US)
Pages (from-to)1051-1065
Number of pages15
JournalUnknown Journal
Volume47
Issue number2
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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