Abstract
The major histocompatibility complex (MHC) of vertebrates encodes several classes of cell-surface proteins that play a critical role in regulating immune responses. Class-I gene code for the transplantation antigens, which are required for the lysis of virally infected or neoplastically transformed cells by cytotoxic T cells (T-cell immunosurveillance). Class-II genes produce cell-surface molecules on bone-marrow-derived cells (B cells, T cells, macrophages) that play a role in the cellular interactions leading to the induction of immune responses. A third family of genes, the class-III genes, encode components of the activation portion of the complement pathway. In this paper we discuss our studies involving the class-I and class-II genes of the inbred BALB/c mouse. These studies provide information about the organization of the MHC on chromosome 17 of the mouse.
Original language | English (US) |
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Pages (from-to) | 1051-1065 |
Number of pages | 15 |
Journal | Unknown Journal |
Volume | 47 |
Issue number | 2 |
DOIs | |
State | Published - 1982 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Genetics