Genetic analysis of a papillary thyroid carcinoma in a patient with MEN 1

D. Desai, L. A. McPherson, J. P T Higgins, R. J. Weigel

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Background: MEN1 is an inherited tumor syndrome characterized by the development of tumors of the parathyroid, the anterior pituitary and the pancreatic islets. Tumors of these endocrine glands in MEN1 patients demonstrate loss of heterozygosity “LOH” at the locus of the MEN1 tumor suppressor gene. Menin, the protein encoded by the MEN1 gene, is ubiquitously expressed in endocrine tissue, and less commonly these patients can present with tumors of other endocrine tissues, including thyroid and adrenal. We hypothesize that MEN] gene mutation may be involved in the oncogenesis of other less common tumors. Methods: We report a MEN1 patient who was found to have metastatic papillary thyroid cancer at the time of neck exploration for hyperparathyroidism. Genetic analysis of tumor tissue was performed using one intragenic “D11S4946” and two flanking “D11S4945 and D11S4940” polymorphic markers. Results: Two of the markers were informative. Consistent with previous studies, there was LOH in the parathyroid adenoma identified with the intragenic marker D11S4946. However, the papillary cancer was found to be heterozygous at two informative markers. Conclusions: The lack of obvious LOH of the MEN1 locus in the papillary cancer suggests that, in contrast to parathyroid adenoma, deletion of the MEN1 tumor suppressor gene is not etiologically related to the oncogenesis of the papillary cancer in this patient.

Original languageEnglish (US)
Pages (from-to)342-346
Number of pages5
JournalAnnals of Surgical Oncology
Volume8
Issue number4
DOIs
StatePublished - Jan 1 2001

Keywords

  • Gene
  • LOH
  • MEN1
  • Papillary thyroid cancer
  • Parathyroid

ASJC Scopus subject areas

  • Surgery
  • Oncology

Fingerprint Dive into the research topics of 'Genetic analysis of a papillary thyroid carcinoma in a patient with MEN 1'. Together they form a unique fingerprint.

  • Cite this