Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV)

Bruce Beutler, Philippe Georgel, Sophie Rutschmann, Zhengfan Jiang, Ben Croker, Karine Crozat

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Innate immunity is inherited and is, therefore, particularly susceptible to analysis by classical genetic methods. The 'phenotype first' approach has already revealed the principal receptors of the innate immune system as well as several essential signalling intermediates. It has recently emerged that innate resistance to mouse cytomegalovirus (MCMV) infection depends upon a large number of host genes with non-redundant functions; hence, random germline mutagenesis frequently causes susceptibility to this pathogen. Approximately one in 30 pedigrees derived from N-ethyl-N-nitrosourea-mutagenised progenitors bears a recessive mutation that disrupts resistance to MCMV. Moreover, many of the genes required for resistance to MCMV will undoubtedly prove to have broad roles in immunity, creating resistance to many other microbes. The forward genetics approach offers an excellent opportunity to identify many of the key components of the innate immune system.

Original languageEnglish (US)
Pages (from-to)203-213
Number of pages11
JournalBriefings in Functional Genomics and Proteomics
Volume4
Issue number3
DOIs
StatePublished - Nov 1 2005

Keywords

  • Herpes virus
  • Host resistance
  • Interferon
  • Resistome
  • Toll-like receptors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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