TY - JOUR
T1 - Genetic dissection of innate immunity to infection
T2 - The mouse cytomegalovirus model
AU - Beutler, Bruce
AU - Crozat, Karine
AU - Koziol, James A.
AU - Georgel, Philippe
N1 - Funding Information:
This work was supported by a grant from the National Institutes of Health (5U54 AI054523-02).
PY - 2005/2
Y1 - 2005/2
N2 - Resistance to infection is largely inherited rather than acquired, and is encoded by a definable set of host genes designated the 'resistome'. Logically speaking, piecemeal disruption of the resistome gives us the best chance to define it, and the most spectacular advances in understanding innate immunity have grown from spontaneous or induced germline mutations of the resistome. Mutations induced by random germline mutagenesis have now become so numerous that we are nearly in a position to define the size of the resistome, and both random and targeted mutations give us a fairly nice sketch of its components and how they interact. Our own N-ethyl-N-nitrosourea mutagenesis effort, which recently showed that components of Toll-like receptor signaling are essential constituents of the arsenal against MCMV infections, validated the forward genetic approach as a powerful tool to define the resistome.
AB - Resistance to infection is largely inherited rather than acquired, and is encoded by a definable set of host genes designated the 'resistome'. Logically speaking, piecemeal disruption of the resistome gives us the best chance to define it, and the most spectacular advances in understanding innate immunity have grown from spontaneous or induced germline mutations of the resistome. Mutations induced by random germline mutagenesis have now become so numerous that we are nearly in a position to define the size of the resistome, and both random and targeted mutations give us a fairly nice sketch of its components and how they interact. Our own N-ethyl-N-nitrosourea mutagenesis effort, which recently showed that components of Toll-like receptor signaling are essential constituents of the arsenal against MCMV infections, validated the forward genetic approach as a powerful tool to define the resistome.
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U2 - 10.1016/j.coi.2004.11.004
DO - 10.1016/j.coi.2004.11.004
M3 - Article
C2 - 15653308
AN - SCOPUS:11844277571
SN - 0952-7915
VL - 17
SP - 36
EP - 43
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 1
ER -