Genetic engineering of livestock

V. G. Pursel, C. A. Pinkert, K. F. Miller, D. J. Bolt, R. G. Campbell, R. D. Palmiter, R. L. Brinster, Robert E Hammer

Research output: Contribution to journalArticle

305 Citations (Scopus)

Abstract

Genetic engineering of livestock is expected to have a major effect on the agricultural industry. However, accurate assessment of the consequences of transgene expression is impossible without multigenerational studies. A systematic study of the beneficial and adverse consequences of long-term elevations in the plasma levels of bovine growth hormone (bGH) was conducted on two lines of transgenic pigs. Two successive generations of pigs expressing the bGH gene showed significant improvements in both daily weight gain and feed efficiency and exhibited changes in carcass composition that included a marked reduction in subcutaneous fat. However, long-term elevation of bGH was generally detrimental to health: the pigs had a high incidence of gastric ulcers, arthritis, cardiomegaly, dermatitis, and renal disease. The ability to produce pigs exhibiting only the beneficial, growth-promoting effects of growth hormone by a transgenic approach may require better control of transgene expression, a different genetic background, or a modified husbandry regimen.

Original languageEnglish (US)
Pages (from-to)1281-1288
Number of pages8
JournalScience
Volume244
Issue number4910
StatePublished - 1989

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Genetic Engineering
Livestock
Swine
Transgenes
Subcutaneous Fat
Cardiomegaly
Dermatitis
Stomach Ulcer
Growth Hormone
Weight Gain
Arthritis
Industry
Kidney
Incidence
Health
Growth
Genes
bovine growth hormone

ASJC Scopus subject areas

  • General

Cite this

Pursel, V. G., Pinkert, C. A., Miller, K. F., Bolt, D. J., Campbell, R. G., Palmiter, R. D., ... Hammer, R. E. (1989). Genetic engineering of livestock. Science, 244(4910), 1281-1288.

Genetic engineering of livestock. / Pursel, V. G.; Pinkert, C. A.; Miller, K. F.; Bolt, D. J.; Campbell, R. G.; Palmiter, R. D.; Brinster, R. L.; Hammer, Robert E.

In: Science, Vol. 244, No. 4910, 1989, p. 1281-1288.

Research output: Contribution to journalArticle

Pursel, VG, Pinkert, CA, Miller, KF, Bolt, DJ, Campbell, RG, Palmiter, RD, Brinster, RL & Hammer, RE 1989, 'Genetic engineering of livestock', Science, vol. 244, no. 4910, pp. 1281-1288.
Pursel VG, Pinkert CA, Miller KF, Bolt DJ, Campbell RG, Palmiter RD et al. Genetic engineering of livestock. Science. 1989;244(4910):1281-1288.
Pursel, V. G. ; Pinkert, C. A. ; Miller, K. F. ; Bolt, D. J. ; Campbell, R. G. ; Palmiter, R. D. ; Brinster, R. L. ; Hammer, Robert E. / Genetic engineering of livestock. In: Science. 1989 ; Vol. 244, No. 4910. pp. 1281-1288.
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