Genetic underpinnings of autoimmunity - Lessons from studies in arthritis, diabetes, lupus and multiple sclerosis

Kirthi Raman, Chandra Mohan

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Autoimmunity has been studied for more than four decades, but its genetic origins have remained a mystery. The recent past has witnessed an exponential growth in our understanding of autoimmunity resulting from both forward and reverse genetic approaches. More than 40 genes have been shown to precipitate systemic autoimmunity when genetically manipulated. In addition, reverse genetic studies in various autoimmune diseases have successfully guided researchers to specific locations on the genome that are associated with disease susceptibility. Buried within these genomic intervals lies a further treasure chest of autoimmunity genes. Efforts to unmask these culprit genes have yielded the very first clues about how an elaborate cast of players may be at work to orchestrate autoimmunity.

Original languageEnglish (US)
Pages (from-to)651-659
Number of pages9
JournalCurrent Opinion in Immunology
Volume15
Issue number6
DOIs
StatePublished - Dec 2003

Fingerprint

Autoimmunity
Multiple Sclerosis
Arthritis
Reverse Genetics
Genes
Disease Susceptibility
Autoimmune Diseases
Thorax
Research Personnel
Genome
Growth

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Genetic underpinnings of autoimmunity - Lessons from studies in arthritis, diabetes, lupus and multiple sclerosis. / Raman, Kirthi; Mohan, Chandra.

In: Current Opinion in Immunology, Vol. 15, No. 6, 12.2003, p. 651-659.

Research output: Contribution to journalArticle

@article{bdc8a3c62d67406e9adc7f0574115216,
title = "Genetic underpinnings of autoimmunity - Lessons from studies in arthritis, diabetes, lupus and multiple sclerosis",
abstract = "Autoimmunity has been studied for more than four decades, but its genetic origins have remained a mystery. The recent past has witnessed an exponential growth in our understanding of autoimmunity resulting from both forward and reverse genetic approaches. More than 40 genes have been shown to precipitate systemic autoimmunity when genetically manipulated. In addition, reverse genetic studies in various autoimmune diseases have successfully guided researchers to specific locations on the genome that are associated with disease susceptibility. Buried within these genomic intervals lies a further treasure chest of autoimmunity genes. Efforts to unmask these culprit genes have yielded the very first clues about how an elaborate cast of players may be at work to orchestrate autoimmunity.",
author = "Kirthi Raman and Chandra Mohan",
year = "2003",
month = "12",
doi = "10.1016/j.coi.2003.09.007",
language = "English (US)",
volume = "15",
pages = "651--659",
journal = "Current Opinion in Immunology",
issn = "0952-7915",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Genetic underpinnings of autoimmunity - Lessons from studies in arthritis, diabetes, lupus and multiple sclerosis

AU - Raman, Kirthi

AU - Mohan, Chandra

PY - 2003/12

Y1 - 2003/12

N2 - Autoimmunity has been studied for more than four decades, but its genetic origins have remained a mystery. The recent past has witnessed an exponential growth in our understanding of autoimmunity resulting from both forward and reverse genetic approaches. More than 40 genes have been shown to precipitate systemic autoimmunity when genetically manipulated. In addition, reverse genetic studies in various autoimmune diseases have successfully guided researchers to specific locations on the genome that are associated with disease susceptibility. Buried within these genomic intervals lies a further treasure chest of autoimmunity genes. Efforts to unmask these culprit genes have yielded the very first clues about how an elaborate cast of players may be at work to orchestrate autoimmunity.

AB - Autoimmunity has been studied for more than four decades, but its genetic origins have remained a mystery. The recent past has witnessed an exponential growth in our understanding of autoimmunity resulting from both forward and reverse genetic approaches. More than 40 genes have been shown to precipitate systemic autoimmunity when genetically manipulated. In addition, reverse genetic studies in various autoimmune diseases have successfully guided researchers to specific locations on the genome that are associated with disease susceptibility. Buried within these genomic intervals lies a further treasure chest of autoimmunity genes. Efforts to unmask these culprit genes have yielded the very first clues about how an elaborate cast of players may be at work to orchestrate autoimmunity.

UR - http://www.scopus.com/inward/record.url?scp=0242407715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242407715&partnerID=8YFLogxK

U2 - 10.1016/j.coi.2003.09.007

DO - 10.1016/j.coi.2003.09.007

M3 - Article

C2 - 14630199

AN - SCOPUS:0242407715

VL - 15

SP - 651

EP - 659

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

SN - 0952-7915

IS - 6

ER -