GLOMERULONEPHRITIS WITH DEPOSITION OF AUSTRALIA ANTIGEN-ANTIBODY COMPLEXES IN GLOMERULAR BASEMENT MEMBRANE

Burton Combes, James Shorey, Arnaldo Barrera, Peter Stastny, EdwinH Eigenbrodt, AlanR Hull, NormanW Carter

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Abstract

A patient with persistent Australia (Au) antigenæmia after post-transfusion hepatitis developed membranous glomerulonephritis. Immunofluorescent staining of kidney tissue revealed glomerular deposits of IgG, complement C3, and Au antigen in a pattern characteristic of immune complex deposition. These findings suggest that Au antigen was involved in the formation of immune complexes whose glomerular deposition initiated the pathologic process leading to the development of diffuse membranous glomerulonephritis.

Original languageEnglish (US)
Pages (from-to)234-237
Number of pages4
JournalThe Lancet
Volume298
Issue number7718
DOIs
Publication statusPublished - Jul 31 1971

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ASJC Scopus subject areas

  • Medicine(all)

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Combes, B., Shorey, J., Barrera, A., Stastny, P., Eigenbrodt, E., Hull, A., & Carter, N. (1971). GLOMERULONEPHRITIS WITH DEPOSITION OF AUSTRALIA ANTIGEN-ANTIBODY COMPLEXES IN GLOMERULAR BASEMENT MEMBRANE. The Lancet, 298(7718), 234-237. https://doi.org/10.1016/S0140-6736(71)92572-4