Glucagon and Blood Sugar

Keith H. Swenson, Robert N. Alsever, Robert S. Sherwin, Philip Felig, Roger H Unger, Rachmiel Levine

Research output: Contribution to journalLetter

5 Citations (Scopus)

Abstract

To the Editor: Sherwin et al., in their article (N Engl J Med 294: 455–461, 1976), and Levine, in his editorial (N Engl J Med 294: 494–495, 1976), concude that glucagon exerts a diabetogenic action only when there is insulin deficiency and not in the normal patient. This point of view is not consistent with findings in the glucagonoma syndrome, which is a rare clinical condition characterized by the association of a distinctive cutaneous eruption with a glucagon-secreting islet-cell neoplasm of the pancreas. Typically, these patients exhibit a diabetic glucose tolerance curve presumably related to high circulating glucagon levels.

Original languageEnglish (US)
Pages (from-to)1238-1240
Number of pages3
JournalNew England Journal of Medicine
Volume294
Issue number22
DOIs
StatePublished - May 27 1976

Fingerprint

Glucagon
Blood Glucose
Glucagon-Secreting Cells
Glucagonoma
Pancreatic Neoplasms
Islets of Langerhans
Insulin
Glucose
Skin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Swenson, K. H., Alsever, R. N., Sherwin, R. S., Felig, P., Unger, R. H., & Levine, R. (1976). Glucagon and Blood Sugar. New England Journal of Medicine, 294(22), 1238-1240. https://doi.org/10.1056/NEJM197605272942218

Glucagon and Blood Sugar. / Swenson, Keith H.; Alsever, Robert N.; Sherwin, Robert S.; Felig, Philip; Unger, Roger H; Levine, Rachmiel.

In: New England Journal of Medicine, Vol. 294, No. 22, 27.05.1976, p. 1238-1240.

Research output: Contribution to journalLetter

Swenson, KH, Alsever, RN, Sherwin, RS, Felig, P, Unger, RH & Levine, R 1976, 'Glucagon and Blood Sugar', New England Journal of Medicine, vol. 294, no. 22, pp. 1238-1240. https://doi.org/10.1056/NEJM197605272942218
Swenson KH, Alsever RN, Sherwin RS, Felig P, Unger RH, Levine R. Glucagon and Blood Sugar. New England Journal of Medicine. 1976 May 27;294(22):1238-1240. https://doi.org/10.1056/NEJM197605272942218
Swenson, Keith H. ; Alsever, Robert N. ; Sherwin, Robert S. ; Felig, Philip ; Unger, Roger H ; Levine, Rachmiel. / Glucagon and Blood Sugar. In: New England Journal of Medicine. 1976 ; Vol. 294, No. 22. pp. 1238-1240.
@article{b33d6f97d501458d949b391e0ca45ee9,
title = "Glucagon and Blood Sugar",
abstract = "To the Editor: Sherwin et al., in their article (N Engl J Med 294: 455–461, 1976), and Levine, in his editorial (N Engl J Med 294: 494–495, 1976), concude that glucagon exerts a diabetogenic action only when there is insulin deficiency and not in the normal patient. This point of view is not consistent with findings in the glucagonoma syndrome, which is a rare clinical condition characterized by the association of a distinctive cutaneous eruption with a glucagon-secreting islet-cell neoplasm of the pancreas. Typically, these patients exhibit a diabetic glucose tolerance curve presumably related to high circulating glucagon levels.",
author = "Swenson, {Keith H.} and Alsever, {Robert N.} and Sherwin, {Robert S.} and Philip Felig and Unger, {Roger H} and Rachmiel Levine",
year = "1976",
month = "5",
day = "27",
doi = "10.1056/NEJM197605272942218",
language = "English (US)",
volume = "294",
pages = "1238--1240",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "22",

}

TY - JOUR

T1 - Glucagon and Blood Sugar

AU - Swenson, Keith H.

AU - Alsever, Robert N.

AU - Sherwin, Robert S.

AU - Felig, Philip

AU - Unger, Roger H

AU - Levine, Rachmiel

PY - 1976/5/27

Y1 - 1976/5/27

N2 - To the Editor: Sherwin et al., in their article (N Engl J Med 294: 455–461, 1976), and Levine, in his editorial (N Engl J Med 294: 494–495, 1976), concude that glucagon exerts a diabetogenic action only when there is insulin deficiency and not in the normal patient. This point of view is not consistent with findings in the glucagonoma syndrome, which is a rare clinical condition characterized by the association of a distinctive cutaneous eruption with a glucagon-secreting islet-cell neoplasm of the pancreas. Typically, these patients exhibit a diabetic glucose tolerance curve presumably related to high circulating glucagon levels.

AB - To the Editor: Sherwin et al., in their article (N Engl J Med 294: 455–461, 1976), and Levine, in his editorial (N Engl J Med 294: 494–495, 1976), concude that glucagon exerts a diabetogenic action only when there is insulin deficiency and not in the normal patient. This point of view is not consistent with findings in the glucagonoma syndrome, which is a rare clinical condition characterized by the association of a distinctive cutaneous eruption with a glucagon-secreting islet-cell neoplasm of the pancreas. Typically, these patients exhibit a diabetic glucose tolerance curve presumably related to high circulating glucagon levels.

UR - http://www.scopus.com/inward/record.url?scp=0017065782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017065782&partnerID=8YFLogxK

U2 - 10.1056/NEJM197605272942218

DO - 10.1056/NEJM197605272942218

M3 - Letter

C2 - 177868

AN - SCOPUS:0017065782

VL - 294

SP - 1238

EP - 1240

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 22

ER -