Glucagon-like peptide-1 (GLP-1) analogs

Recent advances, new possibilities, and therapeutic implications

Bikash Manandhar, Jung Mo Ahn

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Glucagon-like peptide-1 (GLP-1) is an incretin that plays important physiological roles in glucose homeostasis. Produced from intestine upon food intake, it stimulates insulin secretion and keeps pancreatic β-cells healthy and proliferating. Because of these beneficial effects, it has attracted a great deal of attention in the past decade, and an entirely new line of diabetic therapeutics has emerged based on the peptide. In addition to the therapeutic applications, GLP-1 analogs have demonstrated a potential in molecular imaging of pancreatic β-cells; this may be useful in early detection of the disease and evaluation of therapeutic interventions, including islet transplantation. In this Perspective, we focus on GLP-1 analogs for their studies on improvement of biological activities, enhancement of metabolic stability, investigation of receptor interaction, and visualization of the pancreatic islets.

Original languageEnglish (US)
Pages (from-to)1020-1037
Number of pages18
JournalJournal of Medicinal Chemistry
Volume58
Issue number3
DOIs
StatePublished - Feb 12 2015

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Glucagon-Like Peptide 1
Incretins
Islets of Langerhans Transplantation
Molecular Imaging
Islets of Langerhans
Intestines
Early Diagnosis
Homeostasis
Therapeutics
Eating
Insulin
Glucose
Peptides

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Glucagon-like peptide-1 (GLP-1) analogs : Recent advances, new possibilities, and therapeutic implications. / Manandhar, Bikash; Ahn, Jung Mo.

In: Journal of Medicinal Chemistry, Vol. 58, No. 3, 12.02.2015, p. 1020-1037.

Research output: Contribution to journalArticle

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