Glucagon-like peptide-1 (GLP-1) analogs: Recent advances, new possibilities, and therapeutic implications

Bikash Manandhar, Jung Mo Ahn

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Glucagon-like peptide-1 (GLP-1) is an incretin that plays important physiological roles in glucose homeostasis. Produced from intestine upon food intake, it stimulates insulin secretion and keeps pancreatic β-cells healthy and proliferating. Because of these beneficial effects, it has attracted a great deal of attention in the past decade, and an entirely new line of diabetic therapeutics has emerged based on the peptide. In addition to the therapeutic applications, GLP-1 analogs have demonstrated a potential in molecular imaging of pancreatic β-cells; this may be useful in early detection of the disease and evaluation of therapeutic interventions, including islet transplantation. In this Perspective, we focus on GLP-1 analogs for their studies on improvement of biological activities, enhancement of metabolic stability, investigation of receptor interaction, and visualization of the pancreatic islets.

Original languageEnglish (US)
Pages (from-to)1020-1037
Number of pages18
JournalJournal of Medicinal Chemistry
Volume58
Issue number3
DOIs
StatePublished - Feb 12 2015

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ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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