TY - JOUR
T1 - Glucagon Physiology and Pathophysiology
AU - Unger, Roger H
PY - 1971/8/19
Y1 - 1971/8/19
N2 - The function of pancreatic glucagon has been questioned for several decades, but it now seems probable that glucagon, like insulin, is extremely important in the moment-to-moment control of the homeostasis of glucose, of certain amino acids and perhaps of free fatty acids. Normal alpha-cell function seems essential to optimal glucoregulation, and abnormal alpha-cell function may cause, contribute to or result from a variety of metabolic disorders, the most common being diabetes mellitus. Biologic Opposition of Glucagon and Insulin Glucagon has been shown to have potent glycogenolytic1 and gluconeogenic2,3 activity at concentrations within the physiologic range. In addition, it may have.
AB - The function of pancreatic glucagon has been questioned for several decades, but it now seems probable that glucagon, like insulin, is extremely important in the moment-to-moment control of the homeostasis of glucose, of certain amino acids and perhaps of free fatty acids. Normal alpha-cell function seems essential to optimal glucoregulation, and abnormal alpha-cell function may cause, contribute to or result from a variety of metabolic disorders, the most common being diabetes mellitus. Biologic Opposition of Glucagon and Insulin Glucagon has been shown to have potent glycogenolytic1 and gluconeogenic2,3 activity at concentrations within the physiologic range. In addition, it may have.
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U2 - 10.1056/NEJM197108192850806
DO - 10.1056/NEJM197108192850806
M3 - Review article
C2 - 4997492
AN - SCOPUS:0015232603
SN - 0028-4793
VL - 285
SP - 443
EP - 449
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 8
ER -