Gold nanoflowers for 3D volumetric molecular imaging of tumors by photoacoustic tomography

Yuanyuan Jiang, Zijian Deng, Dan Yang, Xin Deng, Qi Li, Yinlin Sha, Changhui Li, Dongsheng Xu

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

By binding molecular probes that target tumor cells, gold nanoparticles (AuNPs) with superior characteristics have shown great potential in tumor molecular imaging studies. The non-invasive, high-resolution, and three-dimensional imaging of the targeted AuNPs within the tumor is desirable for both diagnosis and therapy. In this study, gold nanoflowers (AuNFs) are presented as a novel contrast agent for photoacoustic tomography (PAT). By binding to folic acid, the molecular probe, the tail-vein injected AuNFs concentrated within the tumor site in mice; this was clearly visualized by three-dimensional (3D) PAT imaging. In addition, toxicity assay proved that AuNFs were harmless to living cells and animals. Our results demonstrate that AuNFs have great potential in tumor molecular imaging. [Figure not available: see fulltext.]

Original languageEnglish (US)
Pages (from-to)2152-2161
Number of pages10
JournalNano Research
Volume8
Issue number7
DOIs
StatePublished - Jul 25 2015
Externally publishedYes

Keywords

  • contrast agents
  • gold nanoflowers
  • molecular imaging
  • nanoparticles
  • photoacoustic tomography
  • tumor imaging

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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