Golgi biogenesis

Yanzhuang Wang, Joachim Seemann

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

The Golgi is an essential membrane-bound organelle in the secretary pathway of eukaryotic cells. In mammalian cells, the Golgi stacks are integrated into a continuous perinuclear ribbon, which poses a challenge for the daughter cells to inherit this membrane organelle during cell division. To facilitate proper partitioning, the mammalian Golgi ribbon is disassembled into vesicles in early mitosis. Following segregation into the daughter cells, a functional Golgi is reformed. Here we summarize our current understanding of the molecular mechanisms that control the mitotic Golgi disassembly and postmitotic reassembly cycle in mammalian cells.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalCold Spring Harbor Perspectives in Biology
Volume3
Issue number10
DOIs
StatePublished - Oct 2011

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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