Gonococci damaged the mucosa of human fallopian tubes in organ culture (FTOC), producing characteristic pathologic features. Filter-sterilized supernatant fluid from donor gonococcal-infected FTOC damaged recipient FTOC in a similar fashion. Gonococcal lipopolysaccharide (LPS) was detected in these toxic donor fluids in concentrations of 1.2 to 8.3 μg/ml. Purified gonococcal LPS in concentrations as low as 0.015 μg/ml produced damage equivalent to that caused by toxic donor fluid and was neutralized by polymyxin B. Such LPS-mediated damage to ciliated cells, if it occurs in gonococcal salpingitis, may impair mucociliary flow and predispose to ectopic pregnancy and recurrent ascending infection.
|Original language||English (US)|
|Number of pages||4|
|Journal||American journal of obstetrics and gynecology|
|Issue number||7 PART 2|
|State||Published - Dec 1 1980|
ASJC Scopus subject areas
- Obstetrics and Gynecology