Group 1 mGluR-Dependent Synaptic Long-Term Depression

Mechanisms and Implications for Circuitry and Disease

Christian Lüscher, Kimberly M. Huber

Research output: Contribution to journalArticle

352 Citations (Scopus)

Abstract

Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 mGluRs typically occurs in response to strong activity and triggers long-term plasticity of synaptic transmission in many brain regions, including the neocortex, hippocampus, midbrain, striatum, and cerebellum. Here we focus on mGluR-induced long-term synaptic depression (LTD) and review the literature that implicates Gp1 mGluRs in the plasticity of behavior, learning, and memory. Moreover, recent studies investigating the molecular mechanisms of mGluR-LTD have discovered links to mental retardation, autism, Alzheimer's disease, Parkinson's disease, and drug addiction. We discuss how mGluRs lead to plasticity of neural circuits and how the understanding of the molecular mechanisms of mGluR plasticity provides insight into brain disease.

Original languageEnglish (US)
Pages (from-to)445-459
Number of pages15
JournalNeuron
Volume65
Issue number4
DOIs
StatePublished - Feb 25 2010

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Long-Term Synaptic Depression
Metabotropic Glutamate Receptors
Post-Synaptic Density
Neuronal Plasticity
Neocortex
Brain Diseases
Autistic Disorder
Mesencephalon
Synaptic Transmission
Intellectual Disability
Synapses
Cerebellum
Substance-Related Disorders
Parkinson Disease
Hippocampus
Alzheimer Disease
Learning
Brain

Keywords

  • CELLBIO
  • MOLNEURO
  • SIGNALING

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Group 1 mGluR-Dependent Synaptic Long-Term Depression : Mechanisms and Implications for Circuitry and Disease. / Lüscher, Christian; Huber, Kimberly M.

In: Neuron, Vol. 65, No. 4, 25.02.2010, p. 445-459.

Research output: Contribution to journalArticle

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