Growth of uterine oxygen and glucose uptakes during pregnancy in sheep

F. H. Morriss, C. R. Rosenfeld, R. Resnik, G. Meschia, E. L. Makowski, F. C. Battaglia

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Citations (Scopus)

Abstract

The growth of uterine oxygen and glucose uptakes (QO 2, Q glucose) throughout pregnancy was determined in sheep with chronically implanted uterine artery electromagnetic flow probes and arterial and uterine venous catheters. The flow probe measurements were corrected to total uterine blood flow by means of an equation based on simultaneous flow probe and radioactive microsphere determinations. Uterine QO 2, and Q glucose increased logarithmically as gestation progressed. During the last third of gestation, the mean QO 2 for twin pregnancies was 44% higher than QO 2 for single pregnancies. In the last 3 wk of gestation the uterine glucose/oxygen quotient was 0.76 (95% confidence limits 0.65-0.87), which is significantly less than one and significantly greater than the 0.46 umbilical glucose/oxygen quotient determined in previous studies. This result indicates that substrates other than glucose are used in large amounts in order to satisfy the requirements of uterine oxidative metabolism in late pregnancy and that the placenta has a relatively high glucose/oxygen quotient. Uterine arteriovenous differences of fructose and pyruvate measured at intervals throughout gestation revealed that there is no significant uptake of these substrates by the pregnant uterus.

Original languageEnglish (US)
Title of host publicationGYNEC.INVEST.
Pages230-241
Number of pages12
Volume5
Edition4
StatePublished - 1974

Fingerprint

Sheep
Oxygen
Glucose
Pregnancy
Growth
Umbilicus
Uterine Artery
Twin Pregnancy
Electromagnetic Phenomena
Fructose
Pyruvic Acid
Microspheres
Placenta
Uterus
Catheters

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Morriss, F. H., Rosenfeld, C. R., Resnik, R., Meschia, G., Makowski, E. L., & Battaglia, F. C. (1974). Growth of uterine oxygen and glucose uptakes during pregnancy in sheep. In GYNEC.INVEST. (4 ed., Vol. 5, pp. 230-241)

Growth of uterine oxygen and glucose uptakes during pregnancy in sheep. / Morriss, F. H.; Rosenfeld, C. R.; Resnik, R.; Meschia, G.; Makowski, E. L.; Battaglia, F. C.

GYNEC.INVEST.. Vol. 5 4. ed. 1974. p. 230-241.

Research output: Chapter in Book/Report/Conference proceedingChapter

Morriss, FH, Rosenfeld, CR, Resnik, R, Meschia, G, Makowski, EL & Battaglia, FC 1974, Growth of uterine oxygen and glucose uptakes during pregnancy in sheep. in GYNEC.INVEST.. 4 edn, vol. 5, pp. 230-241.
Morriss FH, Rosenfeld CR, Resnik R, Meschia G, Makowski EL, Battaglia FC. Growth of uterine oxygen and glucose uptakes during pregnancy in sheep. In GYNEC.INVEST.. 4 ed. Vol. 5. 1974. p. 230-241
Morriss, F. H. ; Rosenfeld, C. R. ; Resnik, R. ; Meschia, G. ; Makowski, E. L. ; Battaglia, F. C. / Growth of uterine oxygen and glucose uptakes during pregnancy in sheep. GYNEC.INVEST.. Vol. 5 4. ed. 1974. pp. 230-241
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