TY - JOUR
T1 - H-2M3 encodes the MHC Class I molecule presenting the maternally transmitted antigen of the mouse
AU - Wang, Chyung Ru
AU - Loveland, Bruce E.
AU - Fischer Lindahl, Kirsten
PY - 1991/7/26
Y1 - 1991/7/26
N2 - Mta, the maternally transmitted antigen of mice, is a hydrophobic, N-formylated mitochondrial peptide, MTF, presented on the cell surface to cytotoxic T lymphocytes by a novel major histocompatibility complex class I molecule, encoded by H-2M3. We have cloned and sequenced two alleles of M3, which differ in their ability to present MTF despite 99% identity in the coding regions. M3 is as divergent from classical, antigen-presenting H-2 molecules as from other class I genes of the Hmt and the Qa/Tla regions. Amino acids critical for folding of class I molecules are conserved in M3. Noncharged amino acids lining the peptide-binding groove and phenylalanine 171 may explain the unique interaction with MTF, and leucine 95 appears critical for immunological activity.
AB - Mta, the maternally transmitted antigen of mice, is a hydrophobic, N-formylated mitochondrial peptide, MTF, presented on the cell surface to cytotoxic T lymphocytes by a novel major histocompatibility complex class I molecule, encoded by H-2M3. We have cloned and sequenced two alleles of M3, which differ in their ability to present MTF despite 99% identity in the coding regions. M3 is as divergent from classical, antigen-presenting H-2 molecules as from other class I genes of the Hmt and the Qa/Tla regions. Amino acids critical for folding of class I molecules are conserved in M3. Noncharged amino acids lining the peptide-binding groove and phenylalanine 171 may explain the unique interaction with MTF, and leucine 95 appears critical for immunological activity.
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U2 - 10.1016/0092-8674(91)90623-7
DO - 10.1016/0092-8674(91)90623-7
M3 - Article
C2 - 1855254
AN - SCOPUS:0025781896
SN - 0092-8674
VL - 66
SP - 335
EP - 345
JO - Cell
JF - Cell
IS - 2
ER -