H-2M3 encodes the MHC Class I molecule presenting the maternally transmitted antigen of the mouse

Chyung Ru Wang, Bruce E. Loveland, Kirsten Fischer Lindahl

Research output: Contribution to journalArticle

103 Scopus citations

Abstract

Mta, the maternally transmitted antigen of mice, is a hydrophobic, N-formylated mitochondrial peptide, MTF, presented on the cell surface to cytotoxic T lymphocytes by a novel major histocompatibility complex class I molecule, encoded by H-2M3. We have cloned and sequenced two alleles of M3, which differ in their ability to present MTF despite 99% identity in the coding regions. M3 is as divergent from classical, antigen-presenting H-2 molecules as from other class I genes of the Hmt and the Qa/Tla regions. Amino acids critical for folding of class I molecules are conserved in M3. Noncharged amino acids lining the peptide-binding groove and phenylalanine 171 may explain the unique interaction with MTF, and leucine 95 appears critical for immunological activity.

Original languageEnglish (US)
Pages (from-to)335-345
Number of pages11
JournalCell
Volume66
Issue number2
DOIs
StatePublished - Jul 26 1991

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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