H-2M3 presents a listeria monocytogenes peptide to cytotoxic T lymphocytes

Eric G. Pamer, Chyung Ru Wang, Lorraine Flaherty, Kirsten Fischer Lindahl, Michael J. Bevan

Research output: Contribution to journalArticlepeer-review

179 Scopus citations

Abstract

We report evidence that a major histocompatibility complex-encoded nonclassic class I molecule presents a foreign peptide to cytotoxic T lymphocytes (CTL) during an infection. Mice immunized with virulent Listeria monocytogenes generate CD8+ CTL with αβ receptors specific for a bacterial peptide presented by a conserved class I molecule encoded in the M region of the major histocompatibility complex. The Listeria peptide is digested by carboxypeptidase Y but resists aminopeptidase M, and only peptides with N-formyl methionine competitively block its presentation to CTL. Transfection with the H-2M3d gene enables a negative (H-2w17) cell line to present the bacterial peptide. One function, therefore, of H-2M3 is to present bacterial peptides to CTL during infection.

Original languageEnglish (US)
Pages (from-to)215-223
Number of pages9
JournalCell
Volume70
Issue number2
DOIs
StatePublished - Jul 24 1992

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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