Health-related quality of life in depression

A STAR*D report

Ella J. Daly, Madhukar H. Trivedi, Stephen R. Wisniewski, Andrew A. Nierenberg, Bradley N. Gaynes, Diane Warden, David W. Morris, James F. Luther, Amy Farabaugh, Ian Cook, A. John Rush

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

BACKGROUND: Although major depressive disorder (MDD) is associated with significant impairments in health-related quality of life (HRQOL), few studies have evaluated HRQOL dysfunction in multiple domains. This report examined the psychological, physical, and social domains in a large sample of outpatients who entered the Sequenced Treatment Alternatives to Relieve Depression (STAR&z.ast;D) trial. METHODS: The relationship of HRQOL and baseline sociodemographic and clinical features, including depressive severity, was evaluated. We assessed HRQOL with the 12-item Short Form Health Survey, the 5-item Work and Social Adjustment Scale, and the 16-item Quality of Life Enjoyment and Satisfaction Questionnaire. RESULTS: Among 2307 participants, greater depressive symptom severity was associated with poorer HRQOL. After controlling for age and depression severity, lower HRQOL was related independently to being African American or Hispanic, less educated, unemployed, divorced or separated, having public medical insurance, and to having more general medical disorders. We found impairments across all 3 domains, with low correlations between the 3 measures of HRQOL chosen, suggesting that they evaluate different and nonoverlapping aspects of function. CONCLUSION: Sociodemographically disadvantaged patients with greater general medical and depressive illness burden are at greatest risk for poorer quality of life. Distinct impairments are seen in the 3 domains of HRQOL.

Original languageEnglish (US)
Pages (from-to)43-55
Number of pages13
JournalAnnals of Clinical Psychiatry
Volume22
Issue number1
StatePublished - Feb 2010

Fingerprint

Quality of Life
Depression
Social Adjustment
Cost of Illness
Divorce
Major Depressive Disorder
Vulnerable Populations
Health Surveys
Insurance
Hispanic Americans
African Americans
Outpatients
Psychology

Keywords

  • Domains of quality of life
  • Health-related quality of life
  • Major depressive disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Medicine(all)

Cite this

Daly, E. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Gaynes, B. N., Warden, D., ... Rush, A. J. (2010). Health-related quality of life in depression: A STAR*D report. Annals of Clinical Psychiatry, 22(1), 43-55.

Health-related quality of life in depression : A STAR*D report. / Daly, Ella J.; Trivedi, Madhukar H.; Wisniewski, Stephen R.; Nierenberg, Andrew A.; Gaynes, Bradley N.; Warden, Diane; Morris, David W.; Luther, James F.; Farabaugh, Amy; Cook, Ian; Rush, A. John.

In: Annals of Clinical Psychiatry, Vol. 22, No. 1, 02.2010, p. 43-55.

Research output: Contribution to journalArticle

Daly, EJ, Trivedi, MH, Wisniewski, SR, Nierenberg, AA, Gaynes, BN, Warden, D, Morris, DW, Luther, JF, Farabaugh, A, Cook, I & Rush, AJ 2010, 'Health-related quality of life in depression: A STAR*D report', Annals of Clinical Psychiatry, vol. 22, no. 1, pp. 43-55.
Daly EJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Gaynes BN, Warden D et al. Health-related quality of life in depression: A STAR*D report. Annals of Clinical Psychiatry. 2010 Feb;22(1):43-55.
Daly, Ella J. ; Trivedi, Madhukar H. ; Wisniewski, Stephen R. ; Nierenberg, Andrew A. ; Gaynes, Bradley N. ; Warden, Diane ; Morris, David W. ; Luther, James F. ; Farabaugh, Amy ; Cook, Ian ; Rush, A. John. / Health-related quality of life in depression : A STAR*D report. In: Annals of Clinical Psychiatry. 2010 ; Vol. 22, No. 1. pp. 43-55.
@article{e72cb87b782140e491098f4b5266cddd,
title = "Health-related quality of life in depression: A STAR*D report",
abstract = "BACKGROUND: Although major depressive disorder (MDD) is associated with significant impairments in health-related quality of life (HRQOL), few studies have evaluated HRQOL dysfunction in multiple domains. This report examined the psychological, physical, and social domains in a large sample of outpatients who entered the Sequenced Treatment Alternatives to Relieve Depression (STAR&z.ast;D) trial. METHODS: The relationship of HRQOL and baseline sociodemographic and clinical features, including depressive severity, was evaluated. We assessed HRQOL with the 12-item Short Form Health Survey, the 5-item Work and Social Adjustment Scale, and the 16-item Quality of Life Enjoyment and Satisfaction Questionnaire. RESULTS: Among 2307 participants, greater depressive symptom severity was associated with poorer HRQOL. After controlling for age and depression severity, lower HRQOL was related independently to being African American or Hispanic, less educated, unemployed, divorced or separated, having public medical insurance, and to having more general medical disorders. We found impairments across all 3 domains, with low correlations between the 3 measures of HRQOL chosen, suggesting that they evaluate different and nonoverlapping aspects of function. CONCLUSION: Sociodemographically disadvantaged patients with greater general medical and depressive illness burden are at greatest risk for poorer quality of life. Distinct impairments are seen in the 3 domains of HRQOL.",
keywords = "Domains of quality of life, Health-related quality of life, Major depressive disorder",
author = "Daly, {Ella J.} and Trivedi, {Madhukar H.} and Wisniewski, {Stephen R.} and Nierenberg, {Andrew A.} and Gaynes, {Bradley N.} and Diane Warden and Morris, {David W.} and Luther, {James F.} and Amy Farabaugh and Ian Cook and Rush, {A. John}",
year = "2010",
month = "2",
language = "English (US)",
volume = "22",
pages = "43--55",
journal = "Annals of Clinical Psychiatry",
issn = "1040-1237",
publisher = "Dowden Health Media,Inc",
number = "1",

}

TY - JOUR

T1 - Health-related quality of life in depression

T2 - A STAR*D report

AU - Daly, Ella J.

AU - Trivedi, Madhukar H.

AU - Wisniewski, Stephen R.

AU - Nierenberg, Andrew A.

AU - Gaynes, Bradley N.

AU - Warden, Diane

AU - Morris, David W.

AU - Luther, James F.

AU - Farabaugh, Amy

AU - Cook, Ian

AU - Rush, A. John

PY - 2010/2

Y1 - 2010/2

N2 - BACKGROUND: Although major depressive disorder (MDD) is associated with significant impairments in health-related quality of life (HRQOL), few studies have evaluated HRQOL dysfunction in multiple domains. This report examined the psychological, physical, and social domains in a large sample of outpatients who entered the Sequenced Treatment Alternatives to Relieve Depression (STAR&z.ast;D) trial. METHODS: The relationship of HRQOL and baseline sociodemographic and clinical features, including depressive severity, was evaluated. We assessed HRQOL with the 12-item Short Form Health Survey, the 5-item Work and Social Adjustment Scale, and the 16-item Quality of Life Enjoyment and Satisfaction Questionnaire. RESULTS: Among 2307 participants, greater depressive symptom severity was associated with poorer HRQOL. After controlling for age and depression severity, lower HRQOL was related independently to being African American or Hispanic, less educated, unemployed, divorced or separated, having public medical insurance, and to having more general medical disorders. We found impairments across all 3 domains, with low correlations between the 3 measures of HRQOL chosen, suggesting that they evaluate different and nonoverlapping aspects of function. CONCLUSION: Sociodemographically disadvantaged patients with greater general medical and depressive illness burden are at greatest risk for poorer quality of life. Distinct impairments are seen in the 3 domains of HRQOL.

AB - BACKGROUND: Although major depressive disorder (MDD) is associated with significant impairments in health-related quality of life (HRQOL), few studies have evaluated HRQOL dysfunction in multiple domains. This report examined the psychological, physical, and social domains in a large sample of outpatients who entered the Sequenced Treatment Alternatives to Relieve Depression (STAR&z.ast;D) trial. METHODS: The relationship of HRQOL and baseline sociodemographic and clinical features, including depressive severity, was evaluated. We assessed HRQOL with the 12-item Short Form Health Survey, the 5-item Work and Social Adjustment Scale, and the 16-item Quality of Life Enjoyment and Satisfaction Questionnaire. RESULTS: Among 2307 participants, greater depressive symptom severity was associated with poorer HRQOL. After controlling for age and depression severity, lower HRQOL was related independently to being African American or Hispanic, less educated, unemployed, divorced or separated, having public medical insurance, and to having more general medical disorders. We found impairments across all 3 domains, with low correlations between the 3 measures of HRQOL chosen, suggesting that they evaluate different and nonoverlapping aspects of function. CONCLUSION: Sociodemographically disadvantaged patients with greater general medical and depressive illness burden are at greatest risk for poorer quality of life. Distinct impairments are seen in the 3 domains of HRQOL.

KW - Domains of quality of life

KW - Health-related quality of life

KW - Major depressive disorder

UR - http://www.scopus.com/inward/record.url?scp=77953920180&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953920180&partnerID=8YFLogxK

M3 - Article

VL - 22

SP - 43

EP - 55

JO - Annals of Clinical Psychiatry

JF - Annals of Clinical Psychiatry

SN - 1040-1237

IS - 1

ER -