Hematologic Complications in Patients Hospitalized with COVID-19 Infection

Elisa Lin, Ellen Araj, John Markantonis, Hung Luu, Mingyi Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: This review summarizes data from patients with COVID-19 requiring intensive care unit (ICU) admission. The goals of this study are to showcase some morphological anomalies found in peripheral blood smears from COVID-19 patients and to bring attention to how some hematologic abnormalities in COVID-19 that correspond to disease severity and mortality. Methods: We performed a retrospective analysis of hematologic parameters using peripheral blood smear analysis from 31 COVID-19 patients hospitalized between April 2021 and January 2022. Results: We found abnormal morphology that has not been previously reported. We also report that severe lymphopenia, neutrophilia, acute hemolysis, hematologic malignancies, and increased LDH are associated with ICU admissions, respiratory failure requiring intubation, and poor clinical outcome. Conclusion: We propose these recommendations in the management of COVID-19 patients: 1. Early diagnosis and follow-up of DIC; 2. Optimization of thromboprophylaxis regimen.

Original languageEnglish (US)
Pages (from-to)228-234
Number of pages7
JournalHematology Reports
Volume14
Issue number3
DOIs
StatePublished - Sep 2022

Keywords

  • complications
  • COVID-19
  • hematology
  • hemolysis

ASJC Scopus subject areas

  • Hematology

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