Heme-based sensors: Defining characteristics, recent developments, and regulatory hypotheses

Marie Alda Gilles-Gonzalez, Gonzalo Gonzalez

Research output: Contribution to journalArticlepeer-review

283 Scopus citations

Abstract

In a great variety of organisms throughout all kingdoms of life, the heme-based-sensor proteins are the key regulators of adaptive responses to fluctuating oxygen, carbon monoxide, and nitric oxide levels. These signal transducers achieve their responses by coupling a regulatory heme-binding domain to a neighboring transmitter. The past decade has witnessed an explosion in the numbers of these modular sensory proteins known, from just two recognized members, FixL and soluble guanylyl cyclase (sGC), to four broad families comprising more than 50 sensors. Heme-based sensors so far feature four different types of heme-binding modules: the heme-binding PAS domain, globin-coupled sensor (GCS), CooA, and heme-NO-binding (HNOB). The transmitters for coupling to such heme-binding domains include histidine protein kinases, cyclic nucleotide phosphodiesterases, chemotaxis methyl-carrier protein receptors, and transcription factors of the basic helix-loop-helix and helix-turn-helix classes. Some well-studied sensors are the FixL, EcDos, AxPDEA1, NPAS2, HemAT-Bs, HemAT-Hs, CooA, and sGC proteins. This review elaborates the defining characteristics of heme-based sensors, examines recent developments on those proteins, and discusses the regulatory hypotheses proposed for those sensors. A general, "helix-swap", model is also proposed here for signal transduction by PAS domains.

Original languageEnglish (US)
Pages (from-to)1-22
Number of pages22
JournalJournal of Inorganic Biochemistry
Volume99
Issue number1
DOIs
StatePublished - Jan 2005

Keywords

  • Guanylyl cyclase
  • Hemoglobin
  • Myoglobin
  • Oxygen sensor
  • Response regulator
  • Sensor kinase

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Fingerprint Dive into the research topics of 'Heme-based sensors: Defining characteristics, recent developments, and regulatory hypotheses'. Together they form a unique fingerprint.

Cite this