Hemodynamic effects of intravenous lecithin-based perfluorocarbon emulsions in dogs

R. F. Mattrey, P. L. Hilpert, C. D. Long, D. M. Long, R. M. Mitten, T. Peterson

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

We evaluated and compared the acute hemodynamic effects of perfluorooctylbromide-100% (PFOB), a fluorocarbon emulsified in lecithin without pluronic-F68 (F68), to those of a standard iodinated contrast agent, renografin-76% (R76), and Fluosol-DA 20% (Fluosol), a fluorocarbon emulsified in part by F68. Five open chest dogs were instrumented to evaluate hemodynamic changes after iv injection of PFOB (1 ml·1 g/kg) and R76 (1 ml·037 g of iodine/kg). Fluosol (1 ml·0.2 g/kg) was given to two of the five dogs at the end of their study. Fluosol caused transient hemodynamic collapse in both dogs. R76 caused the known transient effect of hypotension (-15.4 ± 3.3%) followed by hypertension (6.5 ± 2.7%) and an increase in aortic flow (29.3 ± 3.9% at 30 sec). PFOB caused minimal, clinically insignificant decrease in aortic flow (4 ± 1% at 10 sec).

Original languageEnglish (US)
Pages (from-to)652-656
Number of pages5
JournalCritical care medicine
Volume17
Issue number7
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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