We evaluated and compared the acute hemodynamic effects of perfluorooctylbromide-100% (PFOB), a fluorocarbon emulsified in lecithin without pluronic-F68 (F68), to those of a standard iodinated contrast agent, renografin-76% (R76), and Fluosol-DA 20% (Fluosol), a fluorocarbon emulsified in part by F68. Five open chest dogs were instrumented to evaluate hemodynamic changes after iv injection of PFOB (1 ml·1 g/kg) and R76 (1 ml·037 g of iodine/kg). Fluosol (1 ml·0.2 g/kg) was given to two of the five dogs at the end of their study. Fluosol caused transient hemodynamic collapse in both dogs. R76 caused the known transient effect of hypotension (-15.4 ± 3.3%) followed by hypertension (6.5 ± 2.7%) and an increase in aortic flow (29.3 ± 3.9% at 30 sec). PFOB caused minimal, clinically insignificant decrease in aortic flow (4 ± 1% at 10 sec).
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine