Hemorrhagic-ischemic cerebral injury in the preterm infant: Current concepts

Lina Shalak; Jeffrey M. Perlman

doi:10.1016/S0095-5108(02)00048-9

Hemorrhagic-ischemic cerebral injury in the preterm infant: Current concepts

Lina Shalak, Jeffrey M. Perlman

Research output: Contribution to journal › Review article › peer-review

57 Scopus citations

Abstract

PV-IVH and adjacent white matter injury remains a significant problem in the premature infant. The potential mechanisms contributing to injury are complex and involve factors related to blood flow and its regulation, as well as cellular mediators including cytokines, free radical formation, and excitotoxin release. Although a reduction in the occurrence of severe IVH can be achieved with indomethacin, it does translate into long-term neurodevelopmental benefit. This reinforces the concept of a more diffuse injury to brain in sick premature infants than is apparent from the appearance of current neuroimaging techniques.

Original language	English (US)
Pages (from-to)	745-763
Number of pages	19
Journal	Clinics in Perinatology
Volume	29
Issue number	4
DOIs	https://doi.org/10.1016/S0095-5108(02)00048-9
State	Published - Dec 2002

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1016/S0095-5108(02)00048-9

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title = "Hemorrhagic-ischemic cerebral injury in the preterm infant: Current concepts",

abstract = "PV-IVH and adjacent white matter injury remains a significant problem in the premature infant. The potential mechanisms contributing to injury are complex and involve factors related to blood flow and its regulation, as well as cellular mediators including cytokines, free radical formation, and excitotoxin release. Although a reduction in the occurrence of severe IVH can be achieved with indomethacin, it does translate into long-term neurodevelopmental benefit. This reinforces the concept of a more diffuse injury to brain in sick premature infants than is apparent from the appearance of current neuroimaging techniques.",

author = "Lina Shalak and Perlman, {Jeffrey M.}",

note = "Funding Information: Experimental studies have demonstrated vulnerability of the early differentiating oligodendrocyte to free radical injury (eg, hydrogen peroxide, hydroxyl radical) [99,100] . The role for free radical–induced damage triggering the death of the early differentiating oligodendrocyte is supported by the cryoprotection provided by free radical scavengers (eg, superoxide dismutase, desferoxamine, vitamin E) [2,99] . Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

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N2 - PV-IVH and adjacent white matter injury remains a significant problem in the premature infant. The potential mechanisms contributing to injury are complex and involve factors related to blood flow and its regulation, as well as cellular mediators including cytokines, free radical formation, and excitotoxin release. Although a reduction in the occurrence of severe IVH can be achieved with indomethacin, it does translate into long-term neurodevelopmental benefit. This reinforces the concept of a more diffuse injury to brain in sick premature infants than is apparent from the appearance of current neuroimaging techniques.

AB - PV-IVH and adjacent white matter injury remains a significant problem in the premature infant. The potential mechanisms contributing to injury are complex and involve factors related to blood flow and its regulation, as well as cellular mediators including cytokines, free radical formation, and excitotoxin release. Although a reduction in the occurrence of severe IVH can be achieved with indomethacin, it does translate into long-term neurodevelopmental benefit. This reinforces the concept of a more diffuse injury to brain in sick premature infants than is apparent from the appearance of current neuroimaging techniques.

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Hemorrhagic-ischemic cerebral injury in the preterm infant: Current concepts

Abstract

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