HEp-2 cell-adherent escherichia coli in patients with human immunodeficiency virus-associated diarrhea

J. J. Mathewson, Dong Jiang Zhi Dong Jiang, A. Zumla, C. Chintu, N. Luo, S. R. Calamari, R. M. Genta, A. Steephen, P. Schwartz, H. L. DuPont

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Abstract

Diarrhea occurs commonly in African human immunodeficiency virus (HIV) infections. A case-control (HIV-positive vs. -negative) study of adults with diarrhea was done in Lusaka, Zambia, to determine the prevalence of intestinal infection by HEp-2 cell-adherent Escherichia coli. Adherent E. coli were more common in HIV-positive patients with acute diarrhea than among HIV-negative controls (60% vs. 33%) and were found significantly more often in HIV-positive patients with chronic diarrhea than among HIV-negative controls with chronic diarrhea (79% vs. 17%, P <.002). Adherent strains were found significantly more often among HIV-positive patients (69%) than in 22 asymptomatic subjects (36%, P <.02). The HEp-2 cell adherence of the E. coli strains did not show a common pattern. Adherent bacteria were also observed in colonic biopsies from 32% of Zambians with chronic diarrhea who underwent endoscopy. Adherent E. coli may be an important cause of HIV-associated diarrhea in Zambia.

Original languageEnglish (US)
Pages (from-to)1636-1639
Number of pages4
JournalJournal of Infectious Diseases
Volume171
Issue number6
DOIs
StatePublished - Jun 1995

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Mathewson, J. J., Zhi Dong Jiang, D. J., Zumla, A., Chintu, C., Luo, N., Calamari, S. R., Genta, R. M., Steephen, A., Schwartz, P., & DuPont, H. L. (1995). HEp-2 cell-adherent escherichia coli in patients with human immunodeficiency virus-associated diarrhea. Journal of Infectious Diseases, 171(6), 1636-1639. https://doi.org/10.1093/infdis/171.6.1636