HEp-2 cell-adherent Escherichia coli in patients with human immunodeficiency virus-associated diarrhea

J. J. Mathewson, Dong Jiang Zhi Dong Jiang, A. Zumla, C. Chintu, N. Luo, S. R. Calamari, R. M. Genta, A. Steephen, P. Schwartz, H. L. DuPont

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Abstract

Diarrhea occurs commonly in African human immunodeficiency virus (HIV) infections. A case-control (HIV-positive vs. -negative) study of adults with diarrhea was done in Lusaka, Zambia, to determine the prevalence of intestinal infection by HEp-2 cell-adherent Escherichia coli. Adherent E. coli were more common in HIV-positive patients with acute diarrhea than among HIV-negative controls (60% vs. 33%) and were found significantly more often in HIV-positive patients with chronic diarrhea than among HIV-negative controls with chronic diarrhea (79% vs. 17%, P < .002). Adherent strains were found significantly more often among HIV-positive patients (69%) than in 22 asymptomatic subjects (36%, P < .02). The HEp-2 cell adherence of the E. coli strains did not show a common pattern. Adherent bacteria were also observed in colonic biopsies from 32% of Zambians with chronic diarrhea who underwent endoscopy. Adherent E. coli may he an important cause of HIV-associated diarrhea in Zambia.

Original languageEnglish (US)
Pages (from-to)1636-1639
Number of pages4
JournalJournal of Infectious Diseases
Volume171
Issue number6
StatePublished - 1995

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Diarrhea
HIV
Escherichia coli
Zambia
Virus Diseases
Endoscopy
Bacteria
Biopsy
Infection

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Mathewson, J. J., Zhi Dong Jiang, D. J., Zumla, A., Chintu, C., Luo, N., Calamari, S. R., ... DuPont, H. L. (1995). HEp-2 cell-adherent Escherichia coli in patients with human immunodeficiency virus-associated diarrhea. Journal of Infectious Diseases, 171(6), 1636-1639.

HEp-2 cell-adherent Escherichia coli in patients with human immunodeficiency virus-associated diarrhea. / Mathewson, J. J.; Zhi Dong Jiang, Dong Jiang; Zumla, A.; Chintu, C.; Luo, N.; Calamari, S. R.; Genta, R. M.; Steephen, A.; Schwartz, P.; DuPont, H. L.

In: Journal of Infectious Diseases, Vol. 171, No. 6, 1995, p. 1636-1639.

Research output: Contribution to journalArticle

Mathewson, JJ, Zhi Dong Jiang, DJ, Zumla, A, Chintu, C, Luo, N, Calamari, SR, Genta, RM, Steephen, A, Schwartz, P & DuPont, HL 1995, 'HEp-2 cell-adherent Escherichia coli in patients with human immunodeficiency virus-associated diarrhea', Journal of Infectious Diseases, vol. 171, no. 6, pp. 1636-1639.
Mathewson JJ, Zhi Dong Jiang DJ, Zumla A, Chintu C, Luo N, Calamari SR et al. HEp-2 cell-adherent Escherichia coli in patients with human immunodeficiency virus-associated diarrhea. Journal of Infectious Diseases. 1995;171(6):1636-1639.
Mathewson, J. J. ; Zhi Dong Jiang, Dong Jiang ; Zumla, A. ; Chintu, C. ; Luo, N. ; Calamari, S. R. ; Genta, R. M. ; Steephen, A. ; Schwartz, P. ; DuPont, H. L. / HEp-2 cell-adherent Escherichia coli in patients with human immunodeficiency virus-associated diarrhea. In: Journal of Infectious Diseases. 1995 ; Vol. 171, No. 6. pp. 1636-1639.
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