Hepatocyte-specific hmgb1 deletion

Xiaofang Sun, Daolin Tang

Research output: Contribution to journalComment/debate

2 Scopus citations

Abstract

High mobility group box 1 (HMGB1) plays a key role in human health and disease. Currently, three different labs in the USA use Crelox technology to create mice with a hepatocyte-specific Hmgb1 deletion (HMGB1-HC-KO mice) by backcrossing Hmgb1 flox/flox mice to Alb-Cre mice. This mouse strain has a different phenotype following exposure to several stressors.

Original languageEnglish (US)
Pages (from-to)1189-1191
Number of pages3
JournalAutophagy
Volume11
Issue number7
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • HMGB1
  • Knockout
  • Liver
  • Mice

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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