HER-2-targeted nanoparticle-affibody bioconjugates for cancer therapy

Frank Alexis, Pamela Basto, Etgar Levy-Nissenbaum, Aleksandar F. Radovic-Moreno, Liangfang Zhang, Eric Pridgen, Andrew Z. Wang, Shawn L. Marein, Katrina Westerhof, Linda K. Molnar, Omid C. Farokhzad

Research output: Contribution to journalArticlepeer-review

114 Scopus citations

Abstract

(Figure Presented) Affibodies are a class of polypeptide ligand that are potential candidates for tissue-specific targeting of drug-encapsulated controlled release polymeric nanoparticles (NPs). We developed drug delivery vehicles composed of polymeric NPs surface modified with affibody ligands that bind the extracellular domain of the human epidermal growth factor receptor 2 (HER-2) for targeted delivery to cells that overexpress the HER-2 antigen.

Original languageEnglish (US)
Pages (from-to)1839-1843
Number of pages5
JournalChemMedChem
Volume3
Issue number12
DOIs
StatePublished - Dec 15 2008
Externally publishedYes

Keywords

  • Affibodies
  • Antitumor agents
  • Nanoparticles
  • PLA-PEG copolymers
  • Targeted therapy

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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