Her-2/neu (erbB-2) and the cell cycle

D. Busse, R. S. Doughty, C. L. Arteaga

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30 Scopus citations

Abstract

Signaling by the HER-2 proto-oncogene product results in the activation of several biochemical pathways, which in turn modulate the expression and function of cell cycle regulators. These alterations of cell cycle regulatory molecules may be critical for the conception and maintenance of the transformed phenotype conferred by HER-2 gene amplification and overexpression. On the other hand, blockade of HER-2 function with a therapeutic intent will require the reversal of these effects on cell cycle regulatory molecules in order for these interventions to be effective. Data is presented to suggest that the G1 cyclin DI and the cyclin-dependent kinase inhibitor p27KIP1 may be involved in subversion of the G1/S traverse by signaling pathways activated by HER-2 function.

Original languageEnglish (US)
Pages (from-to)3-8
Number of pages6
JournalSeminars in oncology
Volume27
Issue number6 SUPPL. 11
StatePublished - Dec 1 2000

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ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Busse, D., Doughty, R. S., & Arteaga, C. L. (2000). Her-2/neu (erbB-2) and the cell cycle. Seminars in oncology, 27(6 SUPPL. 11), 3-8.