Herpes simplex virus from respiratory tract secretions: Epidemiology, clinical characteristics, and outcome in immunocompromised and nonimmunocompromised hosts

Dan Schuller, Cheryl Spessert, Victoria J. Fraser, Daniel M. Goodenberger

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to review the course of patients with herpes simplex virus (HSV) recovered from respiratory tract secretions, and to compare the demographics, clinical characteristics, and outcomes of immunocompromised versus nonimmunocompromised patiente. Patients and Methods: Retrospective review of medical records of 42 consecutive patiente who had respiratory tract cultures positive for HSV-1 between May 1988 and August 1990 at a major university-affiliated hospital. Results: Twenty-seven patiente (64%) were not immunocompromised. On the average, the nonimmunocompromised patiente were 20 years older (mean age: 67 ± 15, p = 0.001), had a higher incidence of tobacco smoking (p = 0.04), and were more frequently endotracheally intubated prior to HSV isolation (p = 0.002). Nonimmuno-compromised patiente more frequently had bronchospasm (44% versus 7%, p = 0.01), leukocytosis (16,400 versus 6,900/mm3, p = 0.001), and difficulty weaning from mechanical ventilation (63% versus 13%, p = 0.002). Mortality was also greater in the nonimmunocompromised group (70% versus 33%, p = 0.02). In addition, for survivors, days of mechanical ventilation (8 ± 7 versus 2 ± 4, p = 0.03), length of stay in the intensive care unit (10 ± 8 versus 2 ± 4 days, p = 0.004), and length of stay in the hospital (37 ± 23 versus 16 ± 14 days, p = 0.04) were all significantly longer for the nonimmunocompromised patiente. Conclusion: These data suggest that HSV isolation from lower respiratory secretions is associated with a more severe presentation and a worse outcome in immunocompetent patiente than in immunosuppressed patiente.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalThe American journal of medicine
Volume94
Issue number1
DOIs
StatePublished - 1993

Fingerprint

Immunocompromised Host
Simplexvirus
Respiratory System
Epidemiology
Artificial Respiration
Length of Stay
Bronchial Spasm
Leukocytosis
Human Herpesvirus 1
Medical Records
Intensive Care Units
Survivors
Smoking
Demography
Mortality
Incidence

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Herpes simplex virus from respiratory tract secretions : Epidemiology, clinical characteristics, and outcome in immunocompromised and nonimmunocompromised hosts. / Schuller, Dan; Spessert, Cheryl; Fraser, Victoria J.; Goodenberger, Daniel M.

In: The American journal of medicine, Vol. 94, No. 1, 1993, p. 29-33.

Research output: Contribution to journalArticle

@article{ec550957383a4f26a154dd93bd295f8d,
title = "Herpes simplex virus from respiratory tract secretions: Epidemiology, clinical characteristics, and outcome in immunocompromised and nonimmunocompromised hosts",
abstract = "Purpose: The purpose of this study was to review the course of patients with herpes simplex virus (HSV) recovered from respiratory tract secretions, and to compare the demographics, clinical characteristics, and outcomes of immunocompromised versus nonimmunocompromised patiente. Patients and Methods: Retrospective review of medical records of 42 consecutive patiente who had respiratory tract cultures positive for HSV-1 between May 1988 and August 1990 at a major university-affiliated hospital. Results: Twenty-seven patiente (64{\%}) were not immunocompromised. On the average, the nonimmunocompromised patiente were 20 years older (mean age: 67 ± 15, p = 0.001), had a higher incidence of tobacco smoking (p = 0.04), and were more frequently endotracheally intubated prior to HSV isolation (p = 0.002). Nonimmuno-compromised patiente more frequently had bronchospasm (44{\%} versus 7{\%}, p = 0.01), leukocytosis (16,400 versus 6,900/mm3, p = 0.001), and difficulty weaning from mechanical ventilation (63{\%} versus 13{\%}, p = 0.002). Mortality was also greater in the nonimmunocompromised group (70{\%} versus 33{\%}, p = 0.02). In addition, for survivors, days of mechanical ventilation (8 ± 7 versus 2 ± 4, p = 0.03), length of stay in the intensive care unit (10 ± 8 versus 2 ± 4 days, p = 0.004), and length of stay in the hospital (37 ± 23 versus 16 ± 14 days, p = 0.04) were all significantly longer for the nonimmunocompromised patiente. Conclusion: These data suggest that HSV isolation from lower respiratory secretions is associated with a more severe presentation and a worse outcome in immunocompetent patiente than in immunosuppressed patiente.",
author = "Dan Schuller and Cheryl Spessert and Fraser, {Victoria J.} and Goodenberger, {Daniel M.}",
year = "1993",
doi = "10.1016/0002-9343(93)90116-7",
language = "English (US)",
volume = "94",
pages = "29--33",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Herpes simplex virus from respiratory tract secretions

T2 - Epidemiology, clinical characteristics, and outcome in immunocompromised and nonimmunocompromised hosts

AU - Schuller, Dan

AU - Spessert, Cheryl

AU - Fraser, Victoria J.

AU - Goodenberger, Daniel M.

PY - 1993

Y1 - 1993

N2 - Purpose: The purpose of this study was to review the course of patients with herpes simplex virus (HSV) recovered from respiratory tract secretions, and to compare the demographics, clinical characteristics, and outcomes of immunocompromised versus nonimmunocompromised patiente. Patients and Methods: Retrospective review of medical records of 42 consecutive patiente who had respiratory tract cultures positive for HSV-1 between May 1988 and August 1990 at a major university-affiliated hospital. Results: Twenty-seven patiente (64%) were not immunocompromised. On the average, the nonimmunocompromised patiente were 20 years older (mean age: 67 ± 15, p = 0.001), had a higher incidence of tobacco smoking (p = 0.04), and were more frequently endotracheally intubated prior to HSV isolation (p = 0.002). Nonimmuno-compromised patiente more frequently had bronchospasm (44% versus 7%, p = 0.01), leukocytosis (16,400 versus 6,900/mm3, p = 0.001), and difficulty weaning from mechanical ventilation (63% versus 13%, p = 0.002). Mortality was also greater in the nonimmunocompromised group (70% versus 33%, p = 0.02). In addition, for survivors, days of mechanical ventilation (8 ± 7 versus 2 ± 4, p = 0.03), length of stay in the intensive care unit (10 ± 8 versus 2 ± 4 days, p = 0.004), and length of stay in the hospital (37 ± 23 versus 16 ± 14 days, p = 0.04) were all significantly longer for the nonimmunocompromised patiente. Conclusion: These data suggest that HSV isolation from lower respiratory secretions is associated with a more severe presentation and a worse outcome in immunocompetent patiente than in immunosuppressed patiente.

AB - Purpose: The purpose of this study was to review the course of patients with herpes simplex virus (HSV) recovered from respiratory tract secretions, and to compare the demographics, clinical characteristics, and outcomes of immunocompromised versus nonimmunocompromised patiente. Patients and Methods: Retrospective review of medical records of 42 consecutive patiente who had respiratory tract cultures positive for HSV-1 between May 1988 and August 1990 at a major university-affiliated hospital. Results: Twenty-seven patiente (64%) were not immunocompromised. On the average, the nonimmunocompromised patiente were 20 years older (mean age: 67 ± 15, p = 0.001), had a higher incidence of tobacco smoking (p = 0.04), and were more frequently endotracheally intubated prior to HSV isolation (p = 0.002). Nonimmuno-compromised patiente more frequently had bronchospasm (44% versus 7%, p = 0.01), leukocytosis (16,400 versus 6,900/mm3, p = 0.001), and difficulty weaning from mechanical ventilation (63% versus 13%, p = 0.002). Mortality was also greater in the nonimmunocompromised group (70% versus 33%, p = 0.02). In addition, for survivors, days of mechanical ventilation (8 ± 7 versus 2 ± 4, p = 0.03), length of stay in the intensive care unit (10 ± 8 versus 2 ± 4 days, p = 0.004), and length of stay in the hospital (37 ± 23 versus 16 ± 14 days, p = 0.04) were all significantly longer for the nonimmunocompromised patiente. Conclusion: These data suggest that HSV isolation from lower respiratory secretions is associated with a more severe presentation and a worse outcome in immunocompetent patiente than in immunosuppressed patiente.

UR - http://www.scopus.com/inward/record.url?scp=0027402670&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027402670&partnerID=8YFLogxK

U2 - 10.1016/0002-9343(93)90116-7

DO - 10.1016/0002-9343(93)90116-7

M3 - Article

C2 - 8380535

AN - SCOPUS:0027402670

VL - 94

SP - 29

EP - 33

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

IS - 1

ER -