Heterogeneity in Wiedemann-Beckwith syndrome: Anthropometric evidence

Elizabeth S. Moore, Richard E. Ward, Luis F. Escobar, Mary E. Carlin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Wiedemann-Beckwith syndrome (WBS) has attracted a great deal of attention because of its genetic complexity. Individuals with WBS can be identified objectively by anthropometric analysis. Craniofacial anthropometry in conjunction with multivariate statistical analysis can be used to define patterns of variability that appear to relate to specific modes of inheritance that have been proposed for WBS. Our data on 19 affected individuals and their first-degree relatives indicate that the pattern of inheritance rather than the age of subjects may be responsible for the highly variable craniofacial phenotype found in individuals diagnosed with WBS. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)283-290
Number of pages8
JournalAmerican Journal of Medical Genetics
Volume90
Issue number4
DOIs
StatePublished - 2000

Fingerprint

Beckwith-Wiedemann Syndrome
Inheritance Patterns
Anthropometry
Multivariate Analysis
Phenotype

Keywords

  • Craniofacial anthropometry
  • Genomic imprinting
  • Pattern profile
  • Wiedemann-Beckwith

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Heterogeneity in Wiedemann-Beckwith syndrome : Anthropometric evidence. / Moore, Elizabeth S.; Ward, Richard E.; Escobar, Luis F.; Carlin, Mary E.

In: American Journal of Medical Genetics, Vol. 90, No. 4, 2000, p. 283-290.

Research output: Contribution to journalArticle

Moore, Elizabeth S. ; Ward, Richard E. ; Escobar, Luis F. ; Carlin, Mary E. / Heterogeneity in Wiedemann-Beckwith syndrome : Anthropometric evidence. In: American Journal of Medical Genetics. 2000 ; Vol. 90, No. 4. pp. 283-290.
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