High-dose therapy and autologous bone marrow transplantation for intermediate and high grade non-Hodgkin's lymphoma in patients aged 55 years and over: Results from the European Group for Bone Marrow Transplantation

J. W. Sweetenham, R. Pearce, T. Philip, S. J. Proctor, F. Mandelli, P. Colombat, A. H. Goldstone

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

The results of high-dose therapy and autologous BMT for patients with intermediate/high grade NHL were analysed in 82 patients aged ≥ 55 years, identified from the EBMT lymphoma database. These were compared with the results for 82 patients aged < 55 years who were matched on the basis of disease status at transplantation, presence of bone marrow or CNS involvement and closest date of transplantation. The 5 year actuarial progression-free survival (PFS) for patients aged < 55 years was 33% compared with 37% for the ≥ 55 year group (p = 0.08). Corresponding figures for overall survival (OS) were 39% and 38%, respectively (p = 0.19). No difference in outcome was observed according to histological subtype. Although the number of patients receiving total body irradiation (TBI) is small, a significantly lower PFS was observed in patients ≥ 55 years receiving TBI-based high-dose regimens compared with younger patients. This difference was due to a higher toxic death rate in the older patient group. In this retrospective matched analysis, age ≥ 55 years was not associated with lower PFS or OS following high-dose therapy and autologous BMT. The increased toxic death rate in patients receiving TBI suggests that this should be avoided in older patients, who should receive chemotherapy only in high-dose regimens.

Original languageEnglish (US)
Pages (from-to)981-987
Number of pages7
JournalBone Marrow Transplantation
Volume14
Issue number6
StatePublished - Dec 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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