High mobility group box 1 (HMGB1) Phenotypic role revealed with stress

Daolin Tang, Rui Kang, Bennett Van Houten, Herbert J. Zeh, Timothy R. Billiar, Michael T. Lotze

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

High mobility group box 1 (HMGB1) is an evolutionarily ancient protein that is present in one form or another in all eukaryotes. It fundamentally resides in the nucleus but translocates to the cytosol with stress and is subsequently released into the extracellular space. HMGB1 global knockout mice exhibit lethal hypoglycemia, whereas tissues and cells from conditional knockout or knockin mice are born alive without apparent significant functional deficit. An aberrant response to targeted stress in the liver, pancreas, heart or myeloid cells is consistent with a protective role for HMGB1 in sustaining nuclear homeostasis and enabling other stress responses, including autophagy. Under some conditions, HMGB1 is not required for liver and heart function. Many challenges remain with respect to understanding the multiple roles of HMGB1 in health and disease.

Original languageEnglish (US)
Pages (from-to)359-362
Number of pages4
JournalMolecular Medicine
Volume20
Issue number2
DOIs
StatePublished - Jun 6 2014

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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