High plasma free fatty acid levels contribute to the hypersomatostatinemia of insulin deficiency

T. Wasada, B. Howard, K. McCorkle, V. Harris, Roger H Unger

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

High plasma levels of free fatty acids (FFA) stimulate the secretion of splanchnic somatostatin, and both are elevated in insulin deficiency. To determine if the hypersomatostatinemia of insulin deficiency is secondary to high FFA levels, plasma somatostatin-like immunoreactivity (SLI) was measured in a group of insulin-deprived alloxan-diabetic dogs during nicotinic acid-induced lowering of their elevated plasma FFA to normal, and in a group of nondiabetic dogs during nicotinic acid-induced lowering of their FFA to subnormal values. In insulin-deprived diabetic dogs, nicotinic acid reduced plasma FFA from 1.07 ± 0.2 (M ± SE) mmol/L to 0.6 ± 0.1 mmol/L (P < 0.02), approximately the basal FFA level in normal dogs. This was accompanied by a significant decline in plasma SLI levels from a mean baseline of 247 ± 15 pg/ml to a mean nadir of 199 ± 10 pg/ml (P < 0.005). The latter was, nevertheless, significantly above the basal SLI level of the nondiabetic dogs. In contrast, in normal dogs, nicotinic acid-induced reduction in FFA from 0.54 ± 0.02 mmol/L to 0.24 ± 0.03 mmol/L (P < 0.001) was associated with only a small and inconsistent decrease in SLI. These findings suggest that the hypersomatostatinemia of insulin-deficient alloxan-diabetic dogs is, in part, secondary to high plasma FFA levels.

Original languageEnglish (US)
Pages (from-to)358-361
Number of pages4
JournalDiabetes
Volume30
Issue number4
StatePublished - 1981

Fingerprint

Nonesterified Fatty Acids
Insulin
Dogs
Niacin
Alloxan
Viscera
Somatostatin
somatostatin-like peptides

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

High plasma free fatty acid levels contribute to the hypersomatostatinemia of insulin deficiency. / Wasada, T.; Howard, B.; McCorkle, K.; Harris, V.; Unger, Roger H.

In: Diabetes, Vol. 30, No. 4, 1981, p. 358-361.

Research output: Contribution to journalArticle

Wasada, T, Howard, B, McCorkle, K, Harris, V & Unger, RH 1981, 'High plasma free fatty acid levels contribute to the hypersomatostatinemia of insulin deficiency', Diabetes, vol. 30, no. 4, pp. 358-361.
Wasada, T. ; Howard, B. ; McCorkle, K. ; Harris, V. ; Unger, Roger H. / High plasma free fatty acid levels contribute to the hypersomatostatinemia of insulin deficiency. In: Diabetes. 1981 ; Vol. 30, No. 4. pp. 358-361.
@article{c632466964544ceb8f41deb076fef55a,
title = "High plasma free fatty acid levels contribute to the hypersomatostatinemia of insulin deficiency",
abstract = "High plasma levels of free fatty acids (FFA) stimulate the secretion of splanchnic somatostatin, and both are elevated in insulin deficiency. To determine if the hypersomatostatinemia of insulin deficiency is secondary to high FFA levels, plasma somatostatin-like immunoreactivity (SLI) was measured in a group of insulin-deprived alloxan-diabetic dogs during nicotinic acid-induced lowering of their elevated plasma FFA to normal, and in a group of nondiabetic dogs during nicotinic acid-induced lowering of their FFA to subnormal values. In insulin-deprived diabetic dogs, nicotinic acid reduced plasma FFA from 1.07 ± 0.2 (M ± SE) mmol/L to 0.6 ± 0.1 mmol/L (P < 0.02), approximately the basal FFA level in normal dogs. This was accompanied by a significant decline in plasma SLI levels from a mean baseline of 247 ± 15 pg/ml to a mean nadir of 199 ± 10 pg/ml (P < 0.005). The latter was, nevertheless, significantly above the basal SLI level of the nondiabetic dogs. In contrast, in normal dogs, nicotinic acid-induced reduction in FFA from 0.54 ± 0.02 mmol/L to 0.24 ± 0.03 mmol/L (P < 0.001) was associated with only a small and inconsistent decrease in SLI. These findings suggest that the hypersomatostatinemia of insulin-deficient alloxan-diabetic dogs is, in part, secondary to high plasma FFA levels.",
author = "T. Wasada and B. Howard and K. McCorkle and V. Harris and Unger, {Roger H}",
year = "1981",
language = "English (US)",
volume = "30",
pages = "358--361",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "4",

}

TY - JOUR

T1 - High plasma free fatty acid levels contribute to the hypersomatostatinemia of insulin deficiency

AU - Wasada, T.

AU - Howard, B.

AU - McCorkle, K.

AU - Harris, V.

AU - Unger, Roger H

PY - 1981

Y1 - 1981

N2 - High plasma levels of free fatty acids (FFA) stimulate the secretion of splanchnic somatostatin, and both are elevated in insulin deficiency. To determine if the hypersomatostatinemia of insulin deficiency is secondary to high FFA levels, plasma somatostatin-like immunoreactivity (SLI) was measured in a group of insulin-deprived alloxan-diabetic dogs during nicotinic acid-induced lowering of their elevated plasma FFA to normal, and in a group of nondiabetic dogs during nicotinic acid-induced lowering of their FFA to subnormal values. In insulin-deprived diabetic dogs, nicotinic acid reduced plasma FFA from 1.07 ± 0.2 (M ± SE) mmol/L to 0.6 ± 0.1 mmol/L (P < 0.02), approximately the basal FFA level in normal dogs. This was accompanied by a significant decline in plasma SLI levels from a mean baseline of 247 ± 15 pg/ml to a mean nadir of 199 ± 10 pg/ml (P < 0.005). The latter was, nevertheless, significantly above the basal SLI level of the nondiabetic dogs. In contrast, in normal dogs, nicotinic acid-induced reduction in FFA from 0.54 ± 0.02 mmol/L to 0.24 ± 0.03 mmol/L (P < 0.001) was associated with only a small and inconsistent decrease in SLI. These findings suggest that the hypersomatostatinemia of insulin-deficient alloxan-diabetic dogs is, in part, secondary to high plasma FFA levels.

AB - High plasma levels of free fatty acids (FFA) stimulate the secretion of splanchnic somatostatin, and both are elevated in insulin deficiency. To determine if the hypersomatostatinemia of insulin deficiency is secondary to high FFA levels, plasma somatostatin-like immunoreactivity (SLI) was measured in a group of insulin-deprived alloxan-diabetic dogs during nicotinic acid-induced lowering of their elevated plasma FFA to normal, and in a group of nondiabetic dogs during nicotinic acid-induced lowering of their FFA to subnormal values. In insulin-deprived diabetic dogs, nicotinic acid reduced plasma FFA from 1.07 ± 0.2 (M ± SE) mmol/L to 0.6 ± 0.1 mmol/L (P < 0.02), approximately the basal FFA level in normal dogs. This was accompanied by a significant decline in plasma SLI levels from a mean baseline of 247 ± 15 pg/ml to a mean nadir of 199 ± 10 pg/ml (P < 0.005). The latter was, nevertheless, significantly above the basal SLI level of the nondiabetic dogs. In contrast, in normal dogs, nicotinic acid-induced reduction in FFA from 0.54 ± 0.02 mmol/L to 0.24 ± 0.03 mmol/L (P < 0.001) was associated with only a small and inconsistent decrease in SLI. These findings suggest that the hypersomatostatinemia of insulin-deficient alloxan-diabetic dogs is, in part, secondary to high plasma FFA levels.

UR - http://www.scopus.com/inward/record.url?scp=0019453633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019453633&partnerID=8YFLogxK

M3 - Article

VL - 30

SP - 358

EP - 361

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 4

ER -