High potency neuroleptics and violence in schizophrenics

John N. Herrera, John J. Sramek, Jerome F. Costa, Swati Roy, Chris W. Heh, Bich N. Nguyen

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


In a controlled study, inpatient violence was measured during placebo, high-potency (haloperidol) and low-potency (chlorpromazine or clozapine) neuroleptics. Some patients had a marked increase in violent behavior with the moderately high-dose haloperidol, but not with low-potency neuroleptics. The authors discuss reasons for the increased violence with haloperidol, including akathisia and drug-induced behavioral toxicity.

Original languageEnglish (US)
Pages (from-to)558-561
Number of pages4
JournalJournal of Nervous and Mental Disease
Issue number9
StatePublished - Sep 1988
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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