High Prevalence of Low Bone Mineral Density and Substantial Bone Loss over 4 Years among HIV-Infected Persons in the Era of Modern Antiretroviral Therapy

Gerome V. Escota, Kristin Mondy, Tim Bush, Lois Conley, John T. Brooks, Nur Önen, Pragna Patel, Erna Milunka Kojic, Keith Henry, John Hammer, K. C. Wood, Kenneth A. Lichtenstein, Edgar T. Overton

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

HIV-infected persons are living longer on combination antiretroviral therapy (cART) but experiencing more comorbidities including low bone mineral density (BMD). Using data from the Study to Understand the Natural History of HIV and AIDS in the Era of Effective Therapy (SUN Study), we determined the prevalence of low BMD (T-score below one standard deviation of the reference mean) and compared it with matched controls from the National Health and Nutrition Examination Survey (NHANES). We also assessed 4-year longitudinal BMD changes among participants virologically suppressed on cART. Of 653 participants included in this analysis (77% male, 29% black, median age 41 years, median CD4+ cell count 464 cells/mm3, 89% with HIV RNA

Original languageEnglish (US)
Pages (from-to)59-67
Number of pages9
JournalAIDS Research and Human Retroviruses
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2016

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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    Escota, G. V., Mondy, K., Bush, T., Conley, L., Brooks, J. T., Önen, N., Patel, P., Kojic, E. M., Henry, K., Hammer, J., Wood, K. C., Lichtenstein, K. A., & Overton, E. T. (2016). High Prevalence of Low Bone Mineral Density and Substantial Bone Loss over 4 Years among HIV-Infected Persons in the Era of Modern Antiretroviral Therapy. AIDS Research and Human Retroviruses, 32(1), 59-67. https://doi.org/10.1089/aid.2015.0158