High somatostatin uptake by the isolated perfused dog pancreas consistent with an 'insulo-acinar' axis

K. Kawai, L. Orci, Roger H Unger

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The canine pancreas takes up 50-80% of somatostatin perfused over a concentration range of 20 to 4000 pg/ml, compared to <21% of insulin or glucagon. This high uptake by acinar tissue of somatostatin, a potent inhibitor of acinar function, is compatible with a system for selective intrapancreatic control of exocrine pancreatic function via the insulo-acinar portal venous system.

Original languageEnglish (US)
Pages (from-to)660-662
Number of pages3
JournalEndocrinology
Volume110
Issue number2
StatePublished - 1982

Fingerprint

Somatostatin
Pancreas
Dogs
Portal System
Glucagon
Canidae
Insulin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

High somatostatin uptake by the isolated perfused dog pancreas consistent with an 'insulo-acinar' axis. / Kawai, K.; Orci, L.; Unger, Roger H.

In: Endocrinology, Vol. 110, No. 2, 1982, p. 660-662.

Research output: Contribution to journalArticle

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