High somatostatin uptake by the isolated perfused dog pancreas consistent with an 'insulo-acinar' axis

K. Kawai, L. Orci, Roger H Unger

Research output: Contribution to journalArticle

14 Scopus citations


The canine pancreas takes up 50-80% of somatostatin perfused over a concentration range of 20 to 4000 pg/ml, compared to <21% of insulin or glucagon. This high uptake by acinar tissue of somatostatin, a potent inhibitor of acinar function, is compatible with a system for selective intrapancreatic control of exocrine pancreatic function via the insulo-acinar portal venous system.

Original languageEnglish (US)
Pages (from-to)660-662
Number of pages3
Issue number2
Publication statusPublished - 1982


ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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