High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer

N. Tatsumoto, E. Hiyama, Y. Murakami, Y. Imamura, J. W. Shay, Y. Matsuura, T. Yokoyama

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Telomerase activity and altered telomere length have been extensively studied in many kinds of malignant tumors for clinical diagnostic and/or prognostic utilities. In the present study, we investigated telomerase activity and telomere length in colorectal cancers and noncancerous colonic mucosa specimens in 100 patients between 1991 and 1996. To determine whether the level of telomerase activity or telomere length is a prognostic indicator of patient outcome, we followed these patients more than 3 years after surgery. Among 100 primary colorectal cancer specimens, 96 specimens had telomerase activity. Because noncancerous mucosa has some detectable telomerase activity, we divided the levels of telomerase activity into three categories: high (>50-fold more than that in noncancerous mucosa); moderate (10 to 50-fold); and low (<10-fold) levels. Among 100 cancer tissues, 28 showed moderate telomerase activity and 44 showed high telomerase activity. The frequency of tumors with moderate or high telomerase activity showed no significant relationship with any clinicopathological factors. The prognosis of the patients with high telomerase activity was significantly worse than that for patients with moderate and low telomerase activity (P < 0.01). Among the 87 patients with curative surgery, disease-free survival rate of those with high telomerase activity was also significantly poorer (P < 0.01). These results indicate that a high level of telomerase activity may be an independent prognosis-predicting factor in the patients with colorectal cancer.

Original languageEnglish (US)
Pages (from-to)2696-2701
Number of pages6
JournalClinical Cancer Research
Volume6
Issue number7
StatePublished - 2000

Fingerprint

Telomerase
Colorectal Neoplasms
Telomere
Mucous Membrane
Neoplasms
Disease-Free Survival
Survival Rate

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Tatsumoto, N., Hiyama, E., Murakami, Y., Imamura, Y., Shay, J. W., Matsuura, Y., & Yokoyama, T. (2000). High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer. Clinical Cancer Research, 6(7), 2696-2701.

High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer. / Tatsumoto, N.; Hiyama, E.; Murakami, Y.; Imamura, Y.; Shay, J. W.; Matsuura, Y.; Yokoyama, T.

In: Clinical Cancer Research, Vol. 6, No. 7, 2000, p. 2696-2701.

Research output: Contribution to journalArticle

Tatsumoto, N, Hiyama, E, Murakami, Y, Imamura, Y, Shay, JW, Matsuura, Y & Yokoyama, T 2000, 'High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer', Clinical Cancer Research, vol. 6, no. 7, pp. 2696-2701.
Tatsumoto, N. ; Hiyama, E. ; Murakami, Y. ; Imamura, Y. ; Shay, J. W. ; Matsuura, Y. ; Yokoyama, T. / High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer. In: Clinical Cancer Research. 2000 ; Vol. 6, No. 7. pp. 2696-2701.
@article{9d83a956ed9d46fa84079b84c4f4a424,
title = "High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer",
abstract = "Telomerase activity and altered telomere length have been extensively studied in many kinds of malignant tumors for clinical diagnostic and/or prognostic utilities. In the present study, we investigated telomerase activity and telomere length in colorectal cancers and noncancerous colonic mucosa specimens in 100 patients between 1991 and 1996. To determine whether the level of telomerase activity or telomere length is a prognostic indicator of patient outcome, we followed these patients more than 3 years after surgery. Among 100 primary colorectal cancer specimens, 96 specimens had telomerase activity. Because noncancerous mucosa has some detectable telomerase activity, we divided the levels of telomerase activity into three categories: high (>50-fold more than that in noncancerous mucosa); moderate (10 to 50-fold); and low (<10-fold) levels. Among 100 cancer tissues, 28 showed moderate telomerase activity and 44 showed high telomerase activity. The frequency of tumors with moderate or high telomerase activity showed no significant relationship with any clinicopathological factors. The prognosis of the patients with high telomerase activity was significantly worse than that for patients with moderate and low telomerase activity (P < 0.01). Among the 87 patients with curative surgery, disease-free survival rate of those with high telomerase activity was also significantly poorer (P < 0.01). These results indicate that a high level of telomerase activity may be an independent prognosis-predicting factor in the patients with colorectal cancer.",
author = "N. Tatsumoto and E. Hiyama and Y. Murakami and Y. Imamura and Shay, {J. W.} and Y. Matsuura and T. Yokoyama",
year = "2000",
language = "English (US)",
volume = "6",
pages = "2696--2701",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "7",

}

TY - JOUR

T1 - High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer

AU - Tatsumoto, N.

AU - Hiyama, E.

AU - Murakami, Y.

AU - Imamura, Y.

AU - Shay, J. W.

AU - Matsuura, Y.

AU - Yokoyama, T.

PY - 2000

Y1 - 2000

N2 - Telomerase activity and altered telomere length have been extensively studied in many kinds of malignant tumors for clinical diagnostic and/or prognostic utilities. In the present study, we investigated telomerase activity and telomere length in colorectal cancers and noncancerous colonic mucosa specimens in 100 patients between 1991 and 1996. To determine whether the level of telomerase activity or telomere length is a prognostic indicator of patient outcome, we followed these patients more than 3 years after surgery. Among 100 primary colorectal cancer specimens, 96 specimens had telomerase activity. Because noncancerous mucosa has some detectable telomerase activity, we divided the levels of telomerase activity into three categories: high (>50-fold more than that in noncancerous mucosa); moderate (10 to 50-fold); and low (<10-fold) levels. Among 100 cancer tissues, 28 showed moderate telomerase activity and 44 showed high telomerase activity. The frequency of tumors with moderate or high telomerase activity showed no significant relationship with any clinicopathological factors. The prognosis of the patients with high telomerase activity was significantly worse than that for patients with moderate and low telomerase activity (P < 0.01). Among the 87 patients with curative surgery, disease-free survival rate of those with high telomerase activity was also significantly poorer (P < 0.01). These results indicate that a high level of telomerase activity may be an independent prognosis-predicting factor in the patients with colorectal cancer.

AB - Telomerase activity and altered telomere length have been extensively studied in many kinds of malignant tumors for clinical diagnostic and/or prognostic utilities. In the present study, we investigated telomerase activity and telomere length in colorectal cancers and noncancerous colonic mucosa specimens in 100 patients between 1991 and 1996. To determine whether the level of telomerase activity or telomere length is a prognostic indicator of patient outcome, we followed these patients more than 3 years after surgery. Among 100 primary colorectal cancer specimens, 96 specimens had telomerase activity. Because noncancerous mucosa has some detectable telomerase activity, we divided the levels of telomerase activity into three categories: high (>50-fold more than that in noncancerous mucosa); moderate (10 to 50-fold); and low (<10-fold) levels. Among 100 cancer tissues, 28 showed moderate telomerase activity and 44 showed high telomerase activity. The frequency of tumors with moderate or high telomerase activity showed no significant relationship with any clinicopathological factors. The prognosis of the patients with high telomerase activity was significantly worse than that for patients with moderate and low telomerase activity (P < 0.01). Among the 87 patients with curative surgery, disease-free survival rate of those with high telomerase activity was also significantly poorer (P < 0.01). These results indicate that a high level of telomerase activity may be an independent prognosis-predicting factor in the patients with colorectal cancer.

UR - http://www.scopus.com/inward/record.url?scp=0033942071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033942071&partnerID=8YFLogxK

M3 - Article

C2 - 10914712

AN - SCOPUS:0033942071

VL - 6

SP - 2696

EP - 2701

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 7

ER -