TY - JOUR
T1 - High width variability during spiral drawing
T2 - further evidence of cerebellar dysfunction in essential tremor.
AU - Louis, Elan D.
AU - Gillman, Arthur
AU - Boschung, Sarah
AU - Hess, Christopher W.
AU - Yu, Qiping
AU - Pullman, Seth L.
N1 - Funding Information:
R01 NS042859 from the National Institutes of Health (Bethesda, MD, USA; EDL) and support from the Parkinson Disease Foundation (New York, NY, USA; CWH, SLP).
PY - 2012/12
Y1 - 2012/12
N2 - Essential tremor (ET) is among the most prevalent neurological diseases, yet the location of the primary disease substrate continues to be a matter of debate. The presence of intention tremor and mild gait ataxia suggests an underlying abnormality of the cerebellum and/or cerebellar pathways. Uncovering additional signs of cerebellar dysfunction would further substantiate the proposition that ET is a disease of the cerebellar system. We evaluated 145 ET cases and 34 normal controls clinically and by computerized spiral analysis. Spiral analysis is a program that objectively characterizes kinematic and physiologic features of hand-drawn spirals using specific calculated spiral indices that correlate with spiral shape and motor execution. We used the spiral width variability index (SWVI), a measure of loop-to-loop spiral width variation with the influence of tremor removed, as a metric of drawing ataxia. The SWVI was higher in cases than controls (0.91 ± 1.94, median=0.46 vs. 0.40 ± 0.29, median=0.30, p<0.001). Cases with higher SWVI also had greater intention tremor during the finger-nose-finger maneuver, r=0.27, p=0.001), and cases with intention tremor of the head had the highest SWVI (1.57 ± 3.44, median=0.51, p<0.001). There was a modest association between SWVI and number of missteps during tandem gait (r=0.16, p=0.06). The primary anatomical substrate for ET continues to be a matter of speculation, yet these and other clinical data lend support to the notion that there is an underlying abnormality of the cerebellum and/or its pathways.
AB - Essential tremor (ET) is among the most prevalent neurological diseases, yet the location of the primary disease substrate continues to be a matter of debate. The presence of intention tremor and mild gait ataxia suggests an underlying abnormality of the cerebellum and/or cerebellar pathways. Uncovering additional signs of cerebellar dysfunction would further substantiate the proposition that ET is a disease of the cerebellar system. We evaluated 145 ET cases and 34 normal controls clinically and by computerized spiral analysis. Spiral analysis is a program that objectively characterizes kinematic and physiologic features of hand-drawn spirals using specific calculated spiral indices that correlate with spiral shape and motor execution. We used the spiral width variability index (SWVI), a measure of loop-to-loop spiral width variation with the influence of tremor removed, as a metric of drawing ataxia. The SWVI was higher in cases than controls (0.91 ± 1.94, median=0.46 vs. 0.40 ± 0.29, median=0.30, p<0.001). Cases with higher SWVI also had greater intention tremor during the finger-nose-finger maneuver, r=0.27, p=0.001), and cases with intention tremor of the head had the highest SWVI (1.57 ± 3.44, median=0.51, p<0.001). There was a modest association between SWVI and number of missteps during tandem gait (r=0.16, p=0.06). The primary anatomical substrate for ET continues to be a matter of speculation, yet these and other clinical data lend support to the notion that there is an underlying abnormality of the cerebellum and/or its pathways.
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U2 - 10.1007/s12311-011-0352-4
DO - 10.1007/s12311-011-0352-4
M3 - Article
C2 - 22230985
AN - SCOPUS:85027941836
SN - 1473-4222
VL - 11
SP - 872
EP - 879
JO - Cerebellum (London, England)
JF - Cerebellum (London, England)
IS - 4
ER -