Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose

Michael M. Scott, Mario Perello, Jen Chieh Chuang, Ichiro Sakata, Laurent Gautron, Charlotte E. Lee, Danielle Lauzon, Joel K. Elmquist, Jeffrey M. Zigman

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The neuronal coordination of metabolic homeostasis requires the integration of hormonal signals with multiple interrelated central neuronal circuits to produce appropriate levels of food intake, energy expenditure and fuel availability. Ghrelin, a peripherally produced peptide hormone, circulates at high concentrations during nutrient scarcity. Ghrelin promotes food intake, an action lost in ghrelin receptor null mice and also helps maintain fasting blood glucose levels, ensuring an adequate supply of nutrients to the central nervous system. To better understand mechanisms of ghrelin action, we have examined the roles of ghrelin receptor (GHSR) expression in the mouse hindbrain. Notably, selective hindbrain ghrelin receptor expression was not sufficient to restore ghrelin-stimulated food intake. In contrast, the lowered fasting blood glucose levels observed in ghrelin receptor-deficient mice were returned to wild-type levels by selective re-expression of the ghrelin receptor in the hindbrain. Our results demonstrate the distributed nature of the neurons mediating ghrelin action.

Original languageEnglish (US)
Article numbere44089
JournalPLoS One
Volume7
Issue number8
DOIs
StatePublished - Aug 31 2012

Fingerprint

Ghrelin Receptor
ghrelin
Rhombencephalon
Ghrelin
fasting
Fasting
brain
Glucose
glucose
food intake
Eating
blood glucose
Nutrients
Blood Glucose
mice
Food
peptide hormones
Peptide Hormones
Neurology
energy expenditure

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose. / Scott, Michael M.; Perello, Mario; Chuang, Jen Chieh; Sakata, Ichiro; Gautron, Laurent; Lee, Charlotte E.; Lauzon, Danielle; Elmquist, Joel K.; Zigman, Jeffrey M.

In: PLoS One, Vol. 7, No. 8, e44089, 31.08.2012.

Research output: Contribution to journalArticle

Scott, Michael M. ; Perello, Mario ; Chuang, Jen Chieh ; Sakata, Ichiro ; Gautron, Laurent ; Lee, Charlotte E. ; Lauzon, Danielle ; Elmquist, Joel K. ; Zigman, Jeffrey M. / Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose. In: PLoS One. 2012 ; Vol. 7, No. 8.
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