Hippocampal novelty activations in schizophrenia: Disease and medication effects

Carol A. Tamminga, Binu P. Thomas, Ronald Chin, Perry Mihalakos, Kenneth Youens, Anthony D. Wagner, Alison R. Preston

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We examined hippocampal activation in schizophrenia (SZ) with fMRI BOLD in response to the presentation of novel and familiar scenes. Voxel-wise analysis showed no group differences. However, anatomical region-of-interest analyses contrasting normal (NL), SZ-on-medication (SZ-ON), SZ-off-medication (SZ-OFF) showed substantial differences in MTL-based novelty responding, accounted for by the reduction in novelty responses in the SZ-OFF predominantly in the anterior hippocampus and parahippocampal cortex. These differences in novelty-based activation in the SZ-OFF group represent disease characteristics of schizophrenia without confounding effects of antipsychotic medication and illustrate the tendency of antipsychotic drug treatment to improve memory functions in schizophrenia.

Original languageEnglish (US)
Pages (from-to)157-163
Number of pages7
JournalSchizophrenia Research
Volume138
Issue number2-3
DOIs
StatePublished - Jul 2012

Fingerprint

Schizophrenia
Antipsychotic Agents
Hippocampus
Magnetic Resonance Imaging

Keywords

  • Anti-psychotic drugs
  • Brain imaging
  • Declarative memory
  • FMRI BOLD
  • Hippocampus
  • Psychosis

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Tamminga, C. A., Thomas, B. P., Chin, R., Mihalakos, P., Youens, K., Wagner, A. D., & Preston, A. R. (2012). Hippocampal novelty activations in schizophrenia: Disease and medication effects. Schizophrenia Research, 138(2-3), 157-163. https://doi.org/10.1016/j.schres.2012.03.019

Hippocampal novelty activations in schizophrenia : Disease and medication effects. / Tamminga, Carol A.; Thomas, Binu P.; Chin, Ronald; Mihalakos, Perry; Youens, Kenneth; Wagner, Anthony D.; Preston, Alison R.

In: Schizophrenia Research, Vol. 138, No. 2-3, 07.2012, p. 157-163.

Research output: Contribution to journalArticle

Tamminga, CA, Thomas, BP, Chin, R, Mihalakos, P, Youens, K, Wagner, AD & Preston, AR 2012, 'Hippocampal novelty activations in schizophrenia: Disease and medication effects', Schizophrenia Research, vol. 138, no. 2-3, pp. 157-163. https://doi.org/10.1016/j.schres.2012.03.019
Tamminga, Carol A. ; Thomas, Binu P. ; Chin, Ronald ; Mihalakos, Perry ; Youens, Kenneth ; Wagner, Anthony D. ; Preston, Alison R. / Hippocampal novelty activations in schizophrenia : Disease and medication effects. In: Schizophrenia Research. 2012 ; Vol. 138, No. 2-3. pp. 157-163.
@article{5c03cae87849443389cb4eb05ae4d095,
title = "Hippocampal novelty activations in schizophrenia: Disease and medication effects",
abstract = "We examined hippocampal activation in schizophrenia (SZ) with fMRI BOLD in response to the presentation of novel and familiar scenes. Voxel-wise analysis showed no group differences. However, anatomical region-of-interest analyses contrasting normal (NL), SZ-on-medication (SZ-ON), SZ-off-medication (SZ-OFF) showed substantial differences in MTL-based novelty responding, accounted for by the reduction in novelty responses in the SZ-OFF predominantly in the anterior hippocampus and parahippocampal cortex. These differences in novelty-based activation in the SZ-OFF group represent disease characteristics of schizophrenia without confounding effects of antipsychotic medication and illustrate the tendency of antipsychotic drug treatment to improve memory functions in schizophrenia.",
keywords = "Anti-psychotic drugs, Brain imaging, Declarative memory, FMRI BOLD, Hippocampus, Psychosis",
author = "Tamminga, {Carol A.} and Thomas, {Binu P.} and Ronald Chin and Perry Mihalakos and Kenneth Youens and Wagner, {Anthony D.} and Preston, {Alison R.}",
year = "2012",
month = "7",
doi = "10.1016/j.schres.2012.03.019",
language = "English (US)",
volume = "138",
pages = "157--163",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",
number = "2-3",

}

TY - JOUR

T1 - Hippocampal novelty activations in schizophrenia

T2 - Disease and medication effects

AU - Tamminga, Carol A.

AU - Thomas, Binu P.

AU - Chin, Ronald

AU - Mihalakos, Perry

AU - Youens, Kenneth

AU - Wagner, Anthony D.

AU - Preston, Alison R.

PY - 2012/7

Y1 - 2012/7

N2 - We examined hippocampal activation in schizophrenia (SZ) with fMRI BOLD in response to the presentation of novel and familiar scenes. Voxel-wise analysis showed no group differences. However, anatomical region-of-interest analyses contrasting normal (NL), SZ-on-medication (SZ-ON), SZ-off-medication (SZ-OFF) showed substantial differences in MTL-based novelty responding, accounted for by the reduction in novelty responses in the SZ-OFF predominantly in the anterior hippocampus and parahippocampal cortex. These differences in novelty-based activation in the SZ-OFF group represent disease characteristics of schizophrenia without confounding effects of antipsychotic medication and illustrate the tendency of antipsychotic drug treatment to improve memory functions in schizophrenia.

AB - We examined hippocampal activation in schizophrenia (SZ) with fMRI BOLD in response to the presentation of novel and familiar scenes. Voxel-wise analysis showed no group differences. However, anatomical region-of-interest analyses contrasting normal (NL), SZ-on-medication (SZ-ON), SZ-off-medication (SZ-OFF) showed substantial differences in MTL-based novelty responding, accounted for by the reduction in novelty responses in the SZ-OFF predominantly in the anterior hippocampus and parahippocampal cortex. These differences in novelty-based activation in the SZ-OFF group represent disease characteristics of schizophrenia without confounding effects of antipsychotic medication and illustrate the tendency of antipsychotic drug treatment to improve memory functions in schizophrenia.

KW - Anti-psychotic drugs

KW - Brain imaging

KW - Declarative memory

KW - FMRI BOLD

KW - Hippocampus

KW - Psychosis

UR - http://www.scopus.com/inward/record.url?scp=84862124601&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862124601&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2012.03.019

DO - 10.1016/j.schres.2012.03.019

M3 - Article

C2 - 22480957

AN - SCOPUS:84862124601

VL - 138

SP - 157

EP - 163

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 2-3

ER -