Hippocampal novelty activations in schizophrenia: Disease and medication effects

Carol A. Tamminga; Binu P. Thomas; Ronald Chin; Perry Mihalakos; Kenneth Youens; Anthony D. Wagner; Alison R. Preston

doi:10.1016/j.schres.2012.03.019

Hippocampal novelty activations in schizophrenia: Disease and medication effects

Carol A. Tamminga, Binu P. Thomas, Ronald Chin, Perry Mihalakos, Kenneth Youens, Anthony D. Wagner, Alison R. Preston

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We examined hippocampal activation in schizophrenia (SZ) with fMRI BOLD in response to the presentation of novel and familiar scenes. Voxel-wise analysis showed no group differences. However, anatomical region-of-interest analyses contrasting normal (NL), SZ-on-medication (SZ-ON), SZ-off-medication (SZ-OFF) showed substantial differences in MTL-based novelty responding, accounted for by the reduction in novelty responses in the SZ-OFF predominantly in the anterior hippocampus and parahippocampal cortex. These differences in novelty-based activation in the SZ-OFF group represent disease characteristics of schizophrenia without confounding effects of antipsychotic medication and illustrate the tendency of antipsychotic drug treatment to improve memory functions in schizophrenia.

Original language	English (US)
Pages (from-to)	157-163
Number of pages	7
Journal	Schizophrenia Research
Volume	138
Issue number	2-3
DOIs	https://doi.org/10.1016/j.schres.2012.03.019
State	Published - Jul 2012

Keywords

Anti-psychotic drugs
Brain imaging
Declarative memory
FMRI BOLD
Hippocampus
Psychosis

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2012.03.019

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@article{5c03cae87849443389cb4eb05ae4d095,

title = "Hippocampal novelty activations in schizophrenia: Disease and medication effects",

abstract = "We examined hippocampal activation in schizophrenia (SZ) with fMRI BOLD in response to the presentation of novel and familiar scenes. Voxel-wise analysis showed no group differences. However, anatomical region-of-interest analyses contrasting normal (NL), SZ-on-medication (SZ-ON), SZ-off-medication (SZ-OFF) showed substantial differences in MTL-based novelty responding, accounted for by the reduction in novelty responses in the SZ-OFF predominantly in the anterior hippocampus and parahippocampal cortex. These differences in novelty-based activation in the SZ-OFF group represent disease characteristics of schizophrenia without confounding effects of antipsychotic medication and illustrate the tendency of antipsychotic drug treatment to improve memory functions in schizophrenia.",

keywords = "Anti-psychotic drugs, Brain imaging, Declarative memory, FMRI BOLD, Hippocampus, Psychosis",

author = "Tamminga, {Carol A.} and Thomas, {Binu P.} and Ronald Chin and Perry Mihalakos and Kenneth Youens and Wagner, {Anthony D.} and Preston, {Alison R.}",

note = "Funding Information: This work was supported by MH062236 (CT), MH83957 (CT), and a NARSAD Distinguished Investigator Award (CT) and a NARSAD Young Investigator Award (ARP).",

year = "2012",

month = jul,

doi = "10.1016/j.schres.2012.03.019",

language = "English (US)",

volume = "138",

pages = "157--163",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier",

number = "2-3",

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T2 - Disease and medication effects

AU - Tamminga, Carol A.

AU - Thomas, Binu P.

AU - Chin, Ronald

AU - Mihalakos, Perry

AU - Youens, Kenneth

AU - Wagner, Anthony D.

AU - Preston, Alison R.

N1 - Funding Information: This work was supported by MH062236 (CT), MH83957 (CT), and a NARSAD Distinguished Investigator Award (CT) and a NARSAD Young Investigator Award (ARP).

PY - 2012/7

Y1 - 2012/7

N2 - We examined hippocampal activation in schizophrenia (SZ) with fMRI BOLD in response to the presentation of novel and familiar scenes. Voxel-wise analysis showed no group differences. However, anatomical region-of-interest analyses contrasting normal (NL), SZ-on-medication (SZ-ON), SZ-off-medication (SZ-OFF) showed substantial differences in MTL-based novelty responding, accounted for by the reduction in novelty responses in the SZ-OFF predominantly in the anterior hippocampus and parahippocampal cortex. These differences in novelty-based activation in the SZ-OFF group represent disease characteristics of schizophrenia without confounding effects of antipsychotic medication and illustrate the tendency of antipsychotic drug treatment to improve memory functions in schizophrenia.

AB - We examined hippocampal activation in schizophrenia (SZ) with fMRI BOLD in response to the presentation of novel and familiar scenes. Voxel-wise analysis showed no group differences. However, anatomical region-of-interest analyses contrasting normal (NL), SZ-on-medication (SZ-ON), SZ-off-medication (SZ-OFF) showed substantial differences in MTL-based novelty responding, accounted for by the reduction in novelty responses in the SZ-OFF predominantly in the anterior hippocampus and parahippocampal cortex. These differences in novelty-based activation in the SZ-OFF group represent disease characteristics of schizophrenia without confounding effects of antipsychotic medication and illustrate the tendency of antipsychotic drug treatment to improve memory functions in schizophrenia.

KW - Anti-psychotic drugs

KW - Brain imaging

KW - Declarative memory

KW - FMRI BOLD

KW - Hippocampus

KW - Psychosis

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EP - 163

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 2-3

ER -

Hippocampal novelty activations in schizophrenia: Disease and medication effects

Abstract

Keywords

ASJC Scopus subject areas

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