Hippocampal remodeling and damage by corticosteroids: Implications for mood disorders

E. Sherwood Brown, A. John Rush, Bruce S. McEwen

Research output: Contribution to journalArticle

280 Citations (Scopus)

Abstract

Mood disorders are common, recurrent and disabling illnesses which are frequently associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation and memory loss. The hippocampus provides negative feedback to the HPA axis and has an important role in key aspects of spatial and declarative memory. Thus, hippocampal dysfunction could account for both the memory impairment and neuroendocrine abnormalities found in mood disorders. The critical role of the hippocampus in declarative memory, emotional processing, and vulnerability to stress has been demonstrated in both animal and human studies. Cellular processes in the hippocampus including long-term potentiation, neurogenesis, and dendritic remodeling are currently areas of intense study. Human studies report cognitive impairment consistent with hippocampal dysfunction in depression, bipolar disorder, Cushing's disease, and in those individuals receiving exogenous corticosteroids. This review examines data on the role of corticosteroids in hippocampal remodeling and atrophy in patients with mood disorders. Interventions to prevent or reverse the damaging effects of corticosteroids on the hippocampus are discussed. Copyright (C) 1999 American College of Neuropsychopharmacology.

Original languageEnglish (US)
Pages (from-to)474-484
Number of pages11
JournalNeuropsychopharmacology
Volume21
Issue number4
DOIs
StatePublished - Oct 1999

Fingerprint

Mood Disorders
Hippocampus
Adrenal Cortex Hormones
Pituitary ACTH Hypersecretion
Neuronal Plasticity
Long-Term Potentiation
Neurogenesis
Memory Disorders
Bipolar Disorder
Atrophy
Depression

Keywords

  • Bipolar disorder
  • Corticosteroid
  • Cortisol
  • Depression
  • Hippocampus
  • Memory

ASJC Scopus subject areas

  • Pharmacology

Cite this

Hippocampal remodeling and damage by corticosteroids : Implications for mood disorders. / Brown, E. Sherwood; Rush, A. John; McEwen, Bruce S.

In: Neuropsychopharmacology, Vol. 21, No. 4, 10.1999, p. 474-484.

Research output: Contribution to journalArticle

@article{d4a0b77b72ff48df8765c744d9c82142,
title = "Hippocampal remodeling and damage by corticosteroids: Implications for mood disorders",
abstract = "Mood disorders are common, recurrent and disabling illnesses which are frequently associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation and memory loss. The hippocampus provides negative feedback to the HPA axis and has an important role in key aspects of spatial and declarative memory. Thus, hippocampal dysfunction could account for both the memory impairment and neuroendocrine abnormalities found in mood disorders. The critical role of the hippocampus in declarative memory, emotional processing, and vulnerability to stress has been demonstrated in both animal and human studies. Cellular processes in the hippocampus including long-term potentiation, neurogenesis, and dendritic remodeling are currently areas of intense study. Human studies report cognitive impairment consistent with hippocampal dysfunction in depression, bipolar disorder, Cushing's disease, and in those individuals receiving exogenous corticosteroids. This review examines data on the role of corticosteroids in hippocampal remodeling and atrophy in patients with mood disorders. Interventions to prevent or reverse the damaging effects of corticosteroids on the hippocampus are discussed. Copyright (C) 1999 American College of Neuropsychopharmacology.",
keywords = "Bipolar disorder, Corticosteroid, Cortisol, Depression, Hippocampus, Memory",
author = "Brown, {E. Sherwood} and Rush, {A. John} and McEwen, {Bruce S.}",
year = "1999",
month = "10",
doi = "10.1016/S0893-133X(99)00054-8",
language = "English (US)",
volume = "21",
pages = "474--484",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Hippocampal remodeling and damage by corticosteroids

T2 - Implications for mood disorders

AU - Brown, E. Sherwood

AU - Rush, A. John

AU - McEwen, Bruce S.

PY - 1999/10

Y1 - 1999/10

N2 - Mood disorders are common, recurrent and disabling illnesses which are frequently associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation and memory loss. The hippocampus provides negative feedback to the HPA axis and has an important role in key aspects of spatial and declarative memory. Thus, hippocampal dysfunction could account for both the memory impairment and neuroendocrine abnormalities found in mood disorders. The critical role of the hippocampus in declarative memory, emotional processing, and vulnerability to stress has been demonstrated in both animal and human studies. Cellular processes in the hippocampus including long-term potentiation, neurogenesis, and dendritic remodeling are currently areas of intense study. Human studies report cognitive impairment consistent with hippocampal dysfunction in depression, bipolar disorder, Cushing's disease, and in those individuals receiving exogenous corticosteroids. This review examines data on the role of corticosteroids in hippocampal remodeling and atrophy in patients with mood disorders. Interventions to prevent or reverse the damaging effects of corticosteroids on the hippocampus are discussed. Copyright (C) 1999 American College of Neuropsychopharmacology.

AB - Mood disorders are common, recurrent and disabling illnesses which are frequently associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation and memory loss. The hippocampus provides negative feedback to the HPA axis and has an important role in key aspects of spatial and declarative memory. Thus, hippocampal dysfunction could account for both the memory impairment and neuroendocrine abnormalities found in mood disorders. The critical role of the hippocampus in declarative memory, emotional processing, and vulnerability to stress has been demonstrated in both animal and human studies. Cellular processes in the hippocampus including long-term potentiation, neurogenesis, and dendritic remodeling are currently areas of intense study. Human studies report cognitive impairment consistent with hippocampal dysfunction in depression, bipolar disorder, Cushing's disease, and in those individuals receiving exogenous corticosteroids. This review examines data on the role of corticosteroids in hippocampal remodeling and atrophy in patients with mood disorders. Interventions to prevent or reverse the damaging effects of corticosteroids on the hippocampus are discussed. Copyright (C) 1999 American College of Neuropsychopharmacology.

KW - Bipolar disorder

KW - Corticosteroid

KW - Cortisol

KW - Depression

KW - Hippocampus

KW - Memory

UR - http://www.scopus.com/inward/record.url?scp=0012255780&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0012255780&partnerID=8YFLogxK

U2 - 10.1016/S0893-133X(99)00054-8

DO - 10.1016/S0893-133X(99)00054-8

M3 - Article

C2 - 10481830

AN - SCOPUS:0012255780

VL - 21

SP - 474

EP - 484

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

IS - 4

ER -