Histopathology of peripheral nerves in cutaneous herpesvirus infection

J. Trace Worrell, Clay J. Cockerell

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Cutaneous herpesvirus infection is a common viral disorder manifest by epidermal and/or mucosal vesicle formation. Though it is believed that the virus most likely resides in regional sensory ganglia following primary infection and that cutaneous involvement represents reactivation of a latent infection, the histopathology of cutaneous nerves in sites of disease has not been well characterized. In order to assess and characterize the pathologic changes of these nerves, we retrospectively examined 54 cases of cutaneous and mucosal herpesvirus infection as defined by the presence of diagnostic multinucleate epithelial giant cells that demonstrated vital cytopathic effect. Dermal nerves were evaluable in 48 of 54 cases. All cases showed perineural inflammation that consisted of a dense mixed lymphocyte- polymorphonuclear cell infiltrate. Twenty-six cases exhibited intraneural infiltrations accompanied by Schwann cell hypertrophy with nuclear eosinophilia and pyknosis. Frank neuronal necrosis was present in 21 cases, with viral cytopathic effect evident within neurons of four cakes. The degree of peri- and intraneural inflammation correlated with the severity of the inflammatory response within the dermis in most cases: however, in eight cases there was inflammatory involvement of neurovascular structures distant from and out of proportion to dermal and epidermal changes. Immunoperoxidase staining using a polyvalent antibody to human herpesvirus was performed in two cases and demonstrated viral antigen within nerve twigs. This pattern of peripheral nerve twig inflammation, along with the occurrence of more distant neural involvement, may prove to have diagnostic implications and serve as a clue in the recognition of cutaneous herpesvirus infection, particularly in cases with subtle or absent epidermal alteration. Furthermore, the presence of inflammation within and around nerves as well as degenerative changes suggest that nerve twigs are not passive conduits for viral spread but may be directly involved in infection.

Original languageEnglish (US)
Pages (from-to)133-137
Number of pages5
JournalAmerican Journal of Dermatopathology
Volume19
Issue number2
DOIs
StatePublished - 1997

Fingerprint

Herpesviridae Infections
Peripheral Nerves
Skin
Inflammation
Viral Cytopathogenic Effect
Infection
Sensory Ganglia
Viral Antigens
Herpesviridae
Schwann Cells
Eosinophilia
Giant Cells
Dermis
Hypertrophy
Necrosis
Epithelial Cells
Lymphocytes
Staining and Labeling
Viruses
Neurons

Keywords

  • Herpesvirus
  • Inflammation
  • Peripheral nerves

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

Cite this

Histopathology of peripheral nerves in cutaneous herpesvirus infection. / Worrell, J. Trace; Cockerell, Clay J.

In: American Journal of Dermatopathology, Vol. 19, No. 2, 1997, p. 133-137.

Research output: Contribution to journalArticle

Worrell, J. Trace ; Cockerell, Clay J. / Histopathology of peripheral nerves in cutaneous herpesvirus infection. In: American Journal of Dermatopathology. 1997 ; Vol. 19, No. 2. pp. 133-137.
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