HIV-1 Tat: Its dependence on host factors is crystal clear

Iván D'Orso, Alan D. Frankel

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

HIV-1 transcription is regulated at the level of elongation by the viral Tat protein together with the cellular elongation factor P-TEFb, which is composed of cyclin T1 and Cdk9 subunits. The crystal structure of a Tat: P-TEFb complex (Tahirov, T.H.; Babayeva, N.D.; Varzavand, K.; Cooper, J.J.; Sedore, S.C.; and Price, D.H. Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature 2010, 465, 747-751.) reveals molecular details of Tat and its interactions that have eluded investigators for more than two decades and provides provocative insights into the mechanism of Tat activation.

Original languageEnglish (US)
Pages (from-to)2226-2234
Number of pages9
JournalViruses
Volume2
Issue number10
DOIs
StatePublished - Oct 1 2010

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Keywords

  • HIV-1
  • P-TEFB
  • Retroviruses
  • Tat
  • Transcription

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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