HIV and CXCR4 in a kiss of autophagic death

Beth Levine, Donald L. Sodora

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

AIDS is characterized by CD4+ T lymphocyte depletion, yet the mechanisms underlying this central aspect of HIV pathogenesis are still poorly understood. In this issue of the JCI, Espert et al. identify a mechanism by which the HIV envelope glycoprotein can induce death in uninfected CD4 + T cells (see the related article beginning on page 2161). The HIV envelope glycoprotein interacts with CXC chemokine receptor 4 to activate the lysosomal degradation pathway of autophagy, which is necessary for both apoptotic and non-apoptotic cell death.

Original languageEnglish (US)
Pages (from-to)2078-2080
Number of pages3
JournalJournal of Clinical Investigation
Volume116
Issue number8
DOIs
StatePublished - Aug 1 2006

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HIV
Glycoproteins
Lymphocyte Depletion
CXCR4 Receptors
T-Lymphocytes
Autophagy
Acquired Immunodeficiency Syndrome
Cell Death

ASJC Scopus subject areas

  • Medicine(all)

Cite this

HIV and CXCR4 in a kiss of autophagic death. / Levine, Beth; Sodora, Donald L.

In: Journal of Clinical Investigation, Vol. 116, No. 8, 01.08.2006, p. 2078-2080.

Research output: Contribution to journalArticle

Levine, Beth ; Sodora, Donald L. / HIV and CXCR4 in a kiss of autophagic death. In: Journal of Clinical Investigation. 2006 ; Vol. 116, No. 8. pp. 2078-2080.
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