Abstract
AIDS is characterized by CD4+ T lymphocyte depletion, yet the mechanisms underlying this central aspect of HIV pathogenesis are still poorly understood. In this issue of the JCI, Espert et al. identify a mechanism by which the HIV envelope glycoprotein can induce death in uninfected CD4 + T cells (see the related article beginning on page 2161). The HIV envelope glycoprotein interacts with CXC chemokine receptor 4 to activate the lysosomal degradation pathway of autophagy, which is necessary for both apoptotic and non-apoptotic cell death.
Original language | English (US) |
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Pages (from-to) | 2078-2080 |
Number of pages | 3 |
Journal | Journal of Clinical Investigation |
Volume | 116 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1 2006 |
ASJC Scopus subject areas
- General Medicine