Hormonal induction of increased zinc uptake in mammalian cell cultures: Requirement for RNA and protein synthesis

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The zinc content of HeLa S3 cells is markedly increased after growth in medium containing adrenal glucocorticoid hormones. Studies with inhibitors indicate that the synthesis of RNA and protein is required for enhanced zinc uptake. When protein synthesis is blocked in the presence of the steroid, an intermediate, presumably messenger RNA, which specifies enhanced zinc uptake accumulates and is expressed when the inhibition of protein synthesis is removed.

Original languageEnglish (US)
Pages (from-to)196-199
Number of pages4
JournalScience
Volume165
Issue number3889
StatePublished - 1969

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Zinc
Cell Culture Techniques
RNA
Nucleic Acid Synthesis Inhibitors
Proteins
Protein Synthesis Inhibitors
HeLa Cells
Glucocorticoids
Steroids
Hormones
Messenger RNA
Growth

ASJC Scopus subject areas

  • General

Cite this

Hormonal induction of increased zinc uptake in mammalian cell cultures : Requirement for RNA and protein synthesis. / Cox, Rody P.

In: Science, Vol. 165, No. 3889, 1969, p. 196-199.

Research output: Contribution to journalArticle

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